Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WT-161是一种HDAC6选择性有效抑制剂,IC50值为0.40 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 278 | 现货 | ||
2 mg | ¥ 396 | 现货 | ||
5 mg | ¥ 622 | 现货 | ||
10 mg | ¥ 997 | 现货 | ||
25 mg | ¥ 1,830 | 现货 | ||
50 mg | ¥ 2,970 | 现货 | ||
100 mg | ¥ 3,970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 628 | 现货 |
产品描述 | WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM). |
靶点活性 | HDAC6:0.40 nM |
体外活性 | Treatment of anti-multiple myeloma (MM) cell lines with WT161 triggers the accumulation of acetylated tubulin and cell death in MM cell lines more potently than tubacin. Additionally, WT161 in combination with BTZ induces synergistic cytotoxicity and overcomes BTZ resistance in vitro[1]. |
体内活性 | WT161 significantly inhibits in vivo MCF7 cell growth, associated with downregulation of ERα, in a murine xenograft model[2]. |
动物实验 | Female NCr nu/nu mice were subcutaneously (sc) implanted with 17?-estradiol-sustained release pellets (0.18 mg, 60 day release time). Mice were inoculated sc with 5 × 10^6 MCF-7 cells suspended in 30% Matrigel. After 1 month of growth, mice with measurable tumors (> 50 mm^3) were assigned into cohorts receiving intraperitoneal WT161 daily (80 mg/kg) or into a control group receiving vehicle alone (10% DMSO, 90% PBS). Caliper measurements of the longest perpendicular tumor diameters were performed every alternate day to estimate the tumor volume, using the formula volume = ? x L x W^2. Animals were sacrificed when tumors reached 2 cm or if the mice appeared moribund. For each animal, relative tumor volume was determined by normalizing data to the baseline tumor volume for that animal at the start of treatment. Statistical significance was determined by 2-way ANOVA analysis[2]. |
分子量 | 458.55 |
分子式 | C27H30N4O3 |
CAS No. | 1206731-57-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (218.08 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1808 mL | 10.9039 mL | 21.8079 mL | 54.5197 mL |
5 mM | 0.4362 mL | 2.1808 mL | 4.3616 mL | 10.9039 mL | |
10 mM | 0.2181 mL | 1.0904 mL | 2.1808 mL | 5.452 mL | |
20 mM | 0.109 mL | 0.5452 mL | 1.0904 mL | 2.726 mL | |
50 mM | 0.0436 mL | 0.2181 mL | 0.4362 mL | 1.0904 mL | |
100 mM | 0.0218 mL | 0.109 mL | 0.2181 mL | 0.5452 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
WT-161 1206731-57-8 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Inhibitor inhibit WT161 WT 161 inhibitor