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Visomitin

产品编号 T4168 CAS 934826-68-3

别名: SKQ1

Visomitin (SKQ1) 是一种靶向线粒体的抗氧化剂，表现出高效的线粒体穿透能力和有效的抗氧化能力。

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Visomitin, CAS 934826-68-3

规格	价格/CNY	货期
1 mg	￥ 162	现货
5 mg	￥ 397	现货
10 mg	￥ 589	现货
25 mg	￥ 1,150	现货
50 mg	￥ 1,690	现货
100 mg	￥ 2,550	现货
1 mL * 10 mM (in DMSO)	￥ 563	现货

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纯度: 97.08%

纯度: 95.44%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Visomitin (SKQ1) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).
体外活性	Direct treatment of tumor inﬁltrating leukocytes with Visomitin (SkQ1) does not inﬂuence their cytotoxicity against Panc02 cells. Visomitin reduces heavily the proliferation of human PDAC cells at 500 nM concentration while not affecting the viability of the cell lines.
体内活性	Regarding systemic angiogenic factors, a decrease in KC was observed in the serum of Pancreatic ductal adenocarcinoma (PDAC) bearing mice in the group of continuous treatment with Visomitin (SkQ1). Treatment of the mice with Visomitin increases the level of VEGF molecules. The amount of MIP1a and prolactin is reduced in all Visomitin treatment groups or after the follow-up treatment, respectively. Also, an increase in the IL-6 and IL-13 amount is found in the Visomitin treated groups. TGF-b amount is decreased in the pretreatment setting. On the contrary, all schemes of the Visomitin treatment decrease the NKT cell percentage. The Visomitin treatment has prolonged the median survival of PDAC-bearing mice, but the difference does not reach the level of signiﬁcance deﬁned.
细胞实验	Panc02 cells are treated 48 h with different concentrations of Visomitin (SkQ1). Cell viability after Visomitin treatment is measured with an EZ4U Kit as described by the manufacturers. Brie?y, 20,000 cells per well are seeded in 96-wellplates and let grow overnight. Afterwards, cells are treated without the medium exchange. A substrate compound from the kit is added and the cells are further incubated for 5 hr at 37°C to convert the yellow colored tetrazolium to its red formazan derivate by living cells. The absorbance is measured at 450 nm
动物实验	Female C57BL/6 mice are used in this study. For experiments on both acute and chronic pancreatitis, mice are divided in three groups. Group A (acute pancreatitis (AP) n=8; chronic pancreatitis (CP) n=12) is treated with 5?nmol/kg Visomitin (SkQ1), group B (AP n=8; CP n=12) is the untreated control, and group C (AP n=8; CP n=7) is the sham group, which is injected intraperitoneally with 0.9% NaCl instead of cerulein and is therefore the negative control group without pancreatitis. For experiments on acute pancreatitis, mice are pretreated with Visomitin for 8 weeks prior to induction of pancreatitis. Mice designated for experiments on chronic pancreatitis receive Visomitin at the same concentration for 8 weeks in parallel with induction of pancreatitis

别名	SKQ1
分子量	617.61
分子式	C36H42BrO2P
CAS No.	934826-68-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 55 mg/mL (89.05 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6191 mL	8.0957 mL	16.1914 mL	40.4786 mL
	5 mM	0.3238 mL	1.6191 mL	3.2383 mL	8.0957 mL
	10 mM	0.1619 mL	0.8096 mL	1.6191 mL	4.0479 mL
	20 mM	0.081 mL	0.4048 mL	0.8096 mL	2.0239 mL
	50 mM	0.0324 mL	0.1619 mL	0.3238 mL	0.8096 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Samuilov VD, et al. Effect of Cationic Plastoquinone SkQ1 on Electron Transfer Reactions in Chloroplasts and Mitochondria from Pea Seedlings. Biochemistry (Mosc). 2015 Apr;80(4):417-23 2. Iomdina EN, et al. Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits. Front Biosci (Landmark Ed). 2015 Jan 1;20:892-901 3. Manskikh VN, et al. Effect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice. Biochemistry (Mosc). 2014 Oct;79(10):1136-9.

文献引用

1. Wang X H, Song T Z, Zheng H Y, et al. Jejunal epithelial barrier disruption triggered by reactive oxygen species in early SIV infected rhesus macaques. Free Radical Biology and Medicine. 2021 2. Li Y H, Wang X H, Huang W W, et al.Severe fever with thrombocytopenia syndrome virus induces platelet activation and apoptosis via a reactive oxygen species-dependent pathway.Redox Biology.2023: 102837. 3. Dong W, Wang G, Bai Y, et al.Repurposing an Antioxidant to Kill Mycobacterium tuberculosis by Targeting the 50S Subunit of the Ribosome.Biomolecules.2023, 13(12): 1793.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Visomitin 934826-68-3 Immunology/Inflammation Metabolism NF-Κb Reactive Oxygen Species inhibit Inhibitor SKQ 1 SKQ1 SKQ-1 inhibitor

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Visomitin

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

文献引用

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords