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Valorphin

产品编号 T7306 CAS 144313-54-2

别名: Valorphin TFAsalt

Valorphin (Valorphin TFAsalt) 是内源性血红蛋白 β 链第 33-39 位氨基酸残基，具有阿片类镇痛活性，与大鼠 mu-阿片受体结合，IC50 为 14 nM。它有抗肿瘤活性，也可用于缓解疼痛的研究。

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Valorphin, CAS 144313-54-2

规格	价格/CNY	货期
2 mg	￥ 698	待询
5 mg	￥ 997	待询
10 mg	￥ 1,497	待询
25 mg	￥ 2,987	待询
50 mg	￥ 4,488	待询
100 mg	￥ 6,727	待询

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Valorphin 的其他形式现货产品:

Valorphin TFA(144313-54-2(free base))

其他形式的 Valorphin:

Valorphin TFA(144313-54-2(free base))
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Valorphin (Valorphin TFAsalt) has opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM.
靶点活性	μ opioid:14 nM
体内活性	In vivo model (female BLRB mice with subcutaneously inoculated syngeneic mammary carcinoma), simultaneous treatment with 25 mg/m(2) epirubicin and 1 mg/kg valorphin resulted in 42% of tumor growth inhibition, as compared with the negative control group and 22% inhibition as compared with the epirubcin-treated group (at 20th day of treatment). Survival was significantly improved (69% compared to 39% in the group treated with epirubicin only) at day 26 after the treatment beginning[1].
动物实验	49 mice were randomized in 4 groups: two groups (12 animals each) corresponding to the negative control, the reference group (13 animals) and the experimental group (12 animals). The control and the reference group were treated as in preliminary experiment, the experimental group were injected with the mixture of valorphin (1 mg/kg) and epirubicin (25 mg/m^2), dissolved in 0.9% NaCl solution in distilled water. Three injections (volume 0.2 ml) were made with 6-day intervals. Since no reliable difference in tumor size or lifespan of animals in the two negative control groups were observed, the data obtained in these groups were pooled. At day 20 after the first injection, the size of the tumors were determined as described above. Tumor volumes were calculated using for- mula, inhibition of tumor growth was determined using formula . Percentages of survival were determined for 1-26 days of treatment. The observation was quitted after the total death of the animals in the negative control group[1].

别名	Valorphin TFAsalt
分子量	892.01
分子式	C44H61N9O11
CAS No.	144313-54-2

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Blishchenko E Y , Sazonova O V , Kalinina O A , et al. Antitumor effect of valorphin in vitro and in vivo: Combined action with cytostatic drugs[J]. Cancer Biology & Therapy, 2005, 4(1):125-131. 2. Eyu B , Mernenko O A , Mirkina I I , et al. Tumor Cell Cytolysis Mediated by Valorphin, an Opioid-Like Fragment of Hemoglobin β-Chain[J]. Peptides, 1997, 18(1):79-85.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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