首页 Metabolism NADPH VAS2870
VAS2870
编号 T4359    
CAS 722456-31-7     分子式 C18H12N6OS     分子量 360.4
靶点: NADPH oxidase (NOX);
VAS2870 is a NADPH oxidase (NOX) inhibitor.
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规格 库存 单价 数量
5 mg 上海现货 594.00
10 mg 上海现货 1154.00
25 mg 上海现货 2342.00
50 mg 上海现货 4242.00
100 mg 上海现货 7662.00
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生物活性

产品描述

VAS2870 is a NADPH oxidase (NOX) inhibitor.

靶点活性

NADPH oxidase (NOX),

体外活性

VAS2870 blocks serum-dependent cell growth of FaO rat hepatoma cells. VAS2870 inhibits proliferation of different human hepatocellular carcinoma (HCC) cell lines. VAS2870 pretreatment enhances TGF-b-mediated apoptosis of FaO rat hepatoma cells. VAS2870 is effective to suppress PDGF-BB-dependent activation of NADPH oxidase and subsequent production of intracellular ROS. Furthermore, VAS2870 suppresses PDGF-BB-dependent chemotaxis, but not DNA synthesis. Preincubation with VAS2870 (10 and 20 μM) completely abolishes PDGF-mediated NADPH oxidase activation and ROS production. Preincubation with VAS2870 (0.1-20 μM) does not affect PDGF-induced cell cycle progression. However, it abolishes PDGF-dependent chemotaxis of VSMC in a concentration-dependent manner (100% inhibition at 10 μM). VAS2870 inhibits dose-dependently autocrine increase of cell number in FaO rat hepatoma cells, and almost completely blocked ROS production and thymidine incorporation when used at 25 mM.

体内活性

化学信息

分子量

360.4

分子式

C18H12N6OS

CAS

722456-31-7

溶解度

DMSO: 83.3 mg/mL (231.14 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.775 ml 13.873 ml 27.747 ml
5 mM 0.555 ml 2.775 ml 5.549 ml
10 mM 0.277 ml 1.387 ml 2.775 ml
50 mM 0.055 ml 0.277 ml 0.555 ml
相关化合物库
本产品收录于以下化合物库中:
  • 经典已知活性库
  • 临床期小分子药物库
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