Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VAL-083 (Dianhydrogalactitol) 是一种烷化剂,具有抗肿瘤活性,可在 DNA 上产生 N7 甲基化。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 662 | 现货 | ||
2 mg | ¥ 888 | 现货 | ||
5 mg | ¥ 1,320 | 现货 | ||
10 mg | ¥ 1,980 | 现货 | ||
25 mg | ¥ 3,970 | 现货 | ||
50 mg | ¥ 5,990 | 现货 | ||
100 mg | ¥ 8,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,420 | 现货 |
产品描述 | VAL-083 (Dianhydrogalactitol) is an alkylating compound that creates N7 methylation on DNA. It also has antitumor activity. |
体外活性 | VAL-083 inhibits T98G cell growth in a dose-dependent manner (IC50 <5 μM). VAL-083 inhibits the proliferation of HUVEC and U251 cells at doses of more than 12.5 μg/mL. VAL-083 suppresses U251 and SF188 cell growth and induces apoptosis after 72 h. VAL-083 (5 μM) inhibits the growth of SF188 by ~95%. VAL-083 (3.125, 6.25, 12.5 μg/mL) also suppresses the migration and invasion and reduces MMP2, VEGF, VEGFR2, and FGF2 expression in HUVEC and U251 cells. VAL-083 (1, 2, 5 μM) dose-dependently induces cell cycle arrest at the G2/M phase in the 3 glioma cell lines. VAL-083 activates two parallel signaling cascades, the p53-p21, and the CDC25C-CDK1 cascade. VAL-083 significantly enhances the radiosensitivity of LN229 cells [1][2][3]. |
体内活性 | VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes a reduction in FGFR2 expression at 50 μg/mL. VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor model. VAL-083 (25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in the zebrafish model. VAL-083 (5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58% [2][3]. |
别名 | 1,2:5,6-二脱水半乳糖醇, Dianhydrogalactitol, 去水卫矛醇, Dianhydrodulcitol |
分子量 | 146.14 |
分子式 | C6H10O4 |
CAS No. | 23261-20-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 40 mg/mL (273.71 mM), Sonication is recommended.
DMF: 90 mg/mL (615.85 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMF | 1 mM | 6.8428 mL | 34.2138 mL | 68.4275 mL | 171.0688 mL |
5 mM | 1.3686 mL | 6.8428 mL | 13.6855 mL | 34.2138 mL | |
10 mM | 0.6843 mL | 3.4214 mL | 6.8428 mL | 17.1069 mL | |
20 mM | 0.3421 mL | 1.7107 mL | 3.4214 mL | 8.5534 mL | |
50 mM | 0.1369 mL | 0.6843 mL | 1.3686 mL | 3.4214 mL | |
100 mM | 0.0684 mL | 0.3421 mL | 0.6843 mL | 1.7107 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
VAL-083 23261-20-3 DNA Damage/DNA Repair DNA Alkylator/Crosslinker DNA Alkylation VAL083 1,2:5,6-二脱水半乳糖醇 VAL 083 Inhibitor inhibit Dianhydrogalactitol 去水卫矛醇 Dianhydrodulcitol inhibitor