Urethane

产品编号: T0051 别名:

Carbamic acid ethyl ester,Ethyl carbamate,氨基甲酸乙酯,Ethylurethane

Urethane 是多种食品中发酵形成的副产物，是氨基甲酸的乙酯，具有抑制细菌、海胆卵、原生动物和植物组织生长的作用。

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CAS：51-79-6

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Urethane was an antineoplastic agent .Now is used for other medicinal purposes.

体外活性

urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3].

体内活性

Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1].

Cas No.

51-79-6

分子式

C3H7NO2

分子量

89.094

别名

Carbamic acid ethyl ester;Ethyl carbamate;氨基甲酸乙酯;Ethylurethane;Urethane

参考文献

[1]Xia M, Liu L, Tian C, et al. Pharmacokinetics of sinomenine hydrochloride cubic liquid crystal injection based on microdialysis technology[J]. Journal of Drug Delivery Science and Technology. 2019 Aug 52:553-558 [2]Hara K, et al. Anesth Analg. 2002, 94(2):313–318.[3]Maggi CA, et al. Experientia. 1986, 42(2):109-114.[4]Xia M, Tian C, Liu L, et al. Transdermal Administration of Ibuprofen-Loaded Gel: Preparation, Pharmacokinetic Profile, and Tissue Distribution[J]. AAPS PharmSciTech. 2020, 21(3): 84.[5]Barth AM, et al. J Neurosci. 31(3):851-860.[6]Chu X, Wang X, Tian C, et al. Dual drug-loaded cubic liquid crystal gels for transdermal delivery: inner structure and percutaneous mechanism evaluations. Drug Development and Industrial Pharmacy. 2019: 1-10.[7]Yong Z, Xingqi W, Jie H, et al. Formulation, production, in vitro release and in vivo pharmacokinetics of cinnamaldehyde sub-micron emulsions[J]. Pharmaceutical Development and Technology. 2020: 1-10.

引用文献

[1]Cao J, Huang J, Gui S, et al. Preparation, Synergism, and Biocompatibility of in situ Liquid Crystals Loaded with Sinomenine and 5-Fluorouracil for Treatment of Liver Cancer. International Journal of Nanomedicine. 2021, 16: 3725-3739.[2]Zhang Y, Fan X, Su Z, et al. Pretreatment with metformin prevents microcystin‐LR‐induced tau hyperphosphorylation via mTOR‐dependent PP2A and GSK‐3β activation. Environmental Toxicology. 2021 [3]Liu L, Cao W, Xia M, et al. Self-Emulsifying Drug Delivery System Enhances Tissue Distribution of Cinnamaldehyde by Altering the Properties of the Mucus Layer. AAPS PharmSciTech. 2022, 23(7): 1-16.[4]Xia M, Tian C, Liu L, et al. Transdermal Administration of Ibuprofen-Loaded Gel: Preparation, Pharmacokinetic Profile, and Tissue Distribution. AAPS PharmSciTech. 2020, 21(3): 84 [5]Chu X, Wang X, Tian C, et al. Dual drug-loaded cubic liquid crystal gels for transdermal delivery: inner structure and percutaneous mechanism evaluations. Drug Development and Industrial Pharmacy. 2019: 1-10 [6]Yong Z, Xingqi W, Jie H, et al. Formulation, production, in vitro release and in vivo pharmacokinetics of cinnamaldehyde sub-micron emulsions. Pharmaceutical Development and Technology. 2020: 1-10 [7]Xia M, Liu L, Tian C, et al. Pharmacokinetics of sinomenine hydrochloride cubic liquid crystal injection based on microdialysis technology. Journal of Drug Delivery Science and Technology. 2019 Aug 52:553-558

储存和溶解度

DMSO:125 mg/mL (1403.08 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Urethane 51-79-6

对于各种应用，安全且有效的用药剂量是很有必要的了解更多

体内实验配液计算器

第一步：请输入动物实验的基本信息

剂量 mg/kg

每只动物体重 g

给药体积 ul

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO +

% +

% Tween 80 +

% ddH₂O

% DMSO +

重置计算

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

计算器

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已知质量的化合物在一定体积内形成的溶液的浓度

质量

浓度

体积

分子量

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稀释计算器可以帮助您计算

制备已知体积和浓度溶液所需的化合物质量
将已知质量的化合物溶解到所需浓度所需的溶液体积
已知质量的化合物在一定体积内形成的溶液的浓度

浓度（起始）

体积（起始）

浓度（终点）

体积（终点）

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溶液体积

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配液浓度

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输入化合物的化学式以计算其摩尔质量和元素组成
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分子结构式

总分子量

g/mol

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技术支持

在抑制剂处理说明中可以找到您可能遇到的问题的答案。主题包括如何准备储备溶液，如何存储产品以及基于细胞的测定和动物实验需要特别注意的问题。

Keywords

inhibit carbamic Parasite Urethane narcosis mutagen acid Inhibitor Bacterial Pesticide Carbamic acid ethyl ester clastogen Ethyl carbamate 氨基甲酸乙酯 Ethylurethane 51-79-6

Urethane 相关推荐

相关化合物库推荐该产品包含在如下化合物库中：

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Urethane

Carbamic acid ethyl ester,Ethyl carbamate,氨基甲酸乙酯,Ethylurethane

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