Powder: -20°C for 3 years | In solvent: -80°C for 1 year
U93631 是一种具有新型化学结构的 GABAA 受体配体,IC50 为 100 nM,它在重组 GABAA 受体中诱导 GABA 诱导的全细胞 Cl 电流快速,这种效果随时间依赖性衰减。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 161 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,330 | 现货 | ||
50 mg | ¥ 1,960 | 现货 | ||
100 mg | ¥ 3,730 | 现货 | ||
500 mg | ¥ 7,880 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | GABAA receptor antagonist that binds the picrotoxin site and stabilizes the inactive form of the channel via allosteric interaction. Accelerates the decay of GABA-induced Cl- currents with little effect on peak amplitude. Also inhibits 5-HT3A receptors via a similar mechanism. |
靶点活性 | GABAA:100 nM |
体外活性 | In the presence of U93631 at 5 UM, the peak amplitude decreased as a function of GABA concentration, with the half-maximal inhibitory concentration being approximately 100 nM, which is close to the Kd for the high affinity GABA site(85 nM). It appears that the drug interacts with GABA-bound receptors (at least monoliganded) and accelerates receptor desensitization, rather than acting as an open channel blocker. |
分子量 | 299.37 |
分子式 | C17H21N3O2 |
CAS No. | 152273-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (183.72 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3403 mL | 16.7017 mL | 33.4035 mL | 83.5087 mL |
5 mM | 0.6681 mL | 3.3403 mL | 6.6807 mL | 16.7017 mL | |
10 mM | 0.334 mL | 1.6702 mL | 3.3403 mL | 8.3509 mL | |
20 mM | 0.167 mL | 0.8351 mL | 1.6702 mL | 4.1754 mL | |
50 mM | 0.0668 mL | 0.334 mL | 0.6681 mL | 1.6702 mL | |
100 mM | 0.0334 mL | 0.167 mL | 0.334 mL | 0.8351 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
U93631 152273-12-6 Membrane transporter/Ion channel Neuroscience GABA Receptor U 93631 U-93631 Inhibitor γ-Aminobutyric acid Receptor inhibit Gamma-aminobutyric acid Receptor inhibitor