keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin) 是天然存在的内源性阿片肽、metenkephalin 和 zeta-和 delta-阿片受体激动剂的合成形式,是 mu-阿片受体激动剂,具有潜在的镇痛、神经调节、免疫调节、抗炎、抗肿瘤作用以及镇痛、抗抑郁和胃肠运动调节活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 398 | 现货 | ||
25 mg | ¥ 786 | 现货 | ||
50 mg | ¥ 1,339 | 现货 | ||
100 mg | ¥ 2,179 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 495 | 现货 |
产品描述 | Tyr-Gly-Gly-Phe-Met-OH (Met-Enkephalin), is a naturally occurring, endogenous opioid peptide that inhibits tumor growth via binding to the opioid receptor. |
体外活性 | Tyr-Gly-Gly-Phe-Met-OH,as know as Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems.?MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells.?Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs).?MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells.?All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy.?Furthermore, they reveal a relationship between the endocrine and immune systems. |
别名 | Methionine enkephalin, 蛋氨酸脑啡肽, Met-Enkephalin, [MET5]脑啡肽 |
分子量 | 573.66 |
分子式 | C27H35N5O7S |
CAS No. | 58569-55-4 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (69.73 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7432 mL | 8.716 mL | 17.4319 mL | 43.5798 mL |
5 mM | 0.3486 mL | 1.7432 mL | 3.4864 mL | 8.716 mL | |
10 mM | 0.1743 mL | 0.8716 mL | 1.7432 mL | 4.358 mL | |
20 mM | 0.0872 mL | 0.4358 mL | 0.8716 mL | 2.179 mL | |
50 mM | 0.0349 mL | 0.1743 mL | 0.3486 mL | 0.8716 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tyr-Gly-Gly-Phe-Met-OH 58569-55-4 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Inhibitor Tyr Gly Gly Phe Met OH Methionine enkephalin 蛋氨酸脑啡肽 TyrGlyGlyPheMetOH Met-Enkephalin inhibit [MET5]脑啡肽 inhibitor