Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Trimebutine (Mebutin) 是阿片受体激动剂,有抗毒蕈碱活性。它是解痉剂,可调节肠道和结肠运动,并通过抗毒蕈碱和弱μ-阿片受体激动剂作用缓解腹痛。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 108 | 现货 | ||
100 mg | ¥ 137 | 现货 | ||
500 mg | ¥ 289 | 现货 | ||
1 g | ¥ 413 | 现货 |
产品描述 | Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI disorders. It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. Trimebutine is not an FDA-Approved/Clinical drug, but it is available in Canada and several other international countries. |
别名 | 曲美布汀, Mebutin |
分子量 | 387.47 |
分子式 | C22H29NO5 |
CAS No. | 39133-31-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 47 mg/mL (121.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5808 mL | 12.9042 mL | 25.8084 mL | 64.5211 mL |
5 mM | 0.5162 mL | 2.5808 mL | 5.1617 mL | 12.9042 mL | |
10 mM | 0.2581 mL | 1.2904 mL | 2.5808 mL | 6.4521 mL | |
20 mM | 0.129 mL | 0.6452 mL | 1.2904 mL | 3.2261 mL | |
50 mM | 0.0516 mL | 0.2581 mL | 0.5162 mL | 1.2904 mL | |
100 mM | 0.0258 mL | 0.129 mL | 0.2581 mL | 0.6452 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Trimebutine 39133-31-8 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor 曲美布汀 Inhibitor inhibit Mebutin inhibitor