Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物,可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡,具有抗血管生成和抗肿瘤活性,用于癌症研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 417 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 387 | 现货 |
产品描述 | Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
体外活性 | Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. |
体内活性 | Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors without effect on weight in nude mice[2]. |
细胞实验 | Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres. |
动物实验 | Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2]. |
别名 | Tris(2,3-epoxypropyl) Isocyanurate, Teroxirone, TGIC, 1,3,5-三缩水甘油-S-三嗪三酮, TGI |
分子量 | 297.26 |
分子式 | C12H15N3O6 |
CAS No. | 2451-62-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49 mg/ml (164.83 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3641 mL | 16.8203 mL | 33.6406 mL | 84.1015 mL |
5 mM | 0.6728 mL | 3.3641 mL | 6.7281 mL | 16.8203 mL | |
10 mM | 0.3364 mL | 1.682 mL | 3.3641 mL | 8.4101 mL | |
20 mM | 0.1682 mL | 0.841 mL | 1.682 mL | 4.2051 mL | |
50 mM | 0.0673 mL | 0.3364 mL | 0.6728 mL | 1.682 mL | |
100 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.841 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Triglycidyl isocyanurate 2451-62-9 Apoptosis Tris(2,3-epoxypropyl) Isocyanurate hepatocellular Hep3B Teroxirone Inhibitor TGIC HCC tumor inhibit anticancer agent liver cancer carcinoma NSCLC HepG2 MDM-2/p53 1,3,5-三缩水甘油-S-三嗪三酮 TGI inhibitor