首页 Metabolism NADPH Triclosan
Triclosan
编号 T1314     别名: Irgasan, Cloxifenolum
CAS 3380-34-5     分子式 C12H7Cl3O2     分子量 289.54
靶点: NADPH;
Triclosan is an antibacterial and antifungal agent.
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规格 库存 单价 数量
25 mg 上海现货 148.00
50 mg 上海现货 254.00
100 mg 上海现货 457.00
200 mg 上海现货 823.00
1 mL * 10 mM (in DMSO) 上海现货 385.00
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生物活性

产品描述

Triclosan is an antibacterial and antifungal agent.

靶点活性

NADPH,

体外活性

cancer cells with triclosan at the physiologically related concentrations significantly increases the colony number of the cancer cells assessed by tumor formation assay. Triclosan-treated cells have a mesenchymal-like morphology and decrease the cell-to-cell adhesion. Triclosan-treated cells exhibit decreased E-cadherin while significantly up-regulated levels of EMT markers, namely N-cadherin, vimentin, snail and slug. Triclosan may potentiate cancer cells survival in detached condition and motility via the process of EMT[2].

体内活性

Triclosan plays a pathologic role in promoting tissue fibrogenesis, leading to liver carcinogenesis. It accelerates both HCC development and its long-term effects on liver damage, accompanied by fibrosis and inflammation in mice[1].

细胞实验

CV-1 cells are maintained in DMEM supplemented with 10% FBS, seeded in 96-well plates, and transfected with an expression vector containing a specific nuclear receptor and RXR, along with a luciferase reporter containing the appropriate DNA response element. The assay is first validated with known nuclear receptor ligands as positive controls. For the CAR ligand-binding assay, CV-1 cells are transiently transfected with the expression vector containing the Gal4 DNA-binding domain fused with the ligand-binding domain of murine or human CAR and cotransfected with the luciferase reporter plasmid, mh 100-luc. The day after the transfection, the positive compound of each nuclear receptor or TCS(Triclosan) is added and the cells are incubated for an additional 24 h. The luciferase activities are measured and normalized by β-gal activity.(Only for Reference)

细胞系: CV-1 cells

化学信息

分子量

289.54

分子式

C12H7Cl3O2

CAS

3380-34-5

溶解度

DMSO: >10 mM

Ethanol: 57 mg/mL (196.86 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 3.454 ml 17.269 ml 34.538 ml
5 mM 0.691 ml 3.454 ml 6.908 ml
10 mM 0.345 ml 1.727 ml 3.454 ml
50 mM 0.069 ml 0.345 ml 0.691 ml
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