Tosylchloramide sodium trihydrate

产品编号: T19587

Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.

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Tosylchloramide sodium trihydrate Chemical Structure

CAS：7080-50-4

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Tosylchloramide sodium trihydrate is an agent of disinfectant. It is also used as a biocide in air fresheners and deodorants.

体外活性

After tosylchloramide treatment, Gram-positive growth is reduced by 95% to 100% , regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition[1].

体内活性

In the rat tissues, A dose-dependently significant DNA damage and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats[2]. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress[3]. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day[4].

Cas No.

7080-50-4

分子式

C7H10ClNNaO3S

分子量

246.66

别名

Tosylchloramide sodium trihydrate

参考文献

[1]Kuklina I, et al. Investigation of chloramine-T impact on crayfish Astacus leptodactylus (Esch., 1823) cardiac activity. Environ Sci Pollut Res Int. 2014 Sep;21(17):10262-9.[2]Martínez MA, et al. Induction of cytochrome P450-dependent mixed function oxidase activities and peroxisome proliferation by chloramine-T in male rat liver. Food Chem Toxicol. 2017 Aug;106(Pt A):86-91.[3]Shim I, et al. Inhalation exposure to chloramine T induces DNA damage and inflammation in lung of Sprague-Dawley rats. J Toxicol Sci. 2013;38(6):937-46.[4]Kloth LC, et al. Bactericidal and cytotoxic effects of chloramine-T on wound pathogens and human fibroblasts in vitro. Adv Skin Wound Care. 2007 Jun;20(6):331-45.

储存和溶解度

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Tosylchloramide sodium trihydrate 7080-50-4

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体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

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要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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Keywords

Tosylchloramide sodium trihydrate 7080-50-4

注册成功

Tosylchloramide sodium trihydrate

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