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Toceranib Phosphate

Toceranib Phosphate

产品编号 T7394   CAS 874819-74-6
别名: SU11654 phosphate, PHA 291639 phosphate, 托西尼布磷酸盐

Toceranib Phosphate (SU11654 phosphate) 是有效的、具有口服活性的酪氨酸激酶 (RTK) 受体抑制剂,能抑制PDGFRVEGFR,Kit,抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用,可用于研究犬肥大细胞肿瘤。

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Toceranib Phosphate Chemical Structure
Toceranib Phosphate, CAS 874819-74-6
规格 价格/CNY 货期 数量
5 mg ¥ 255 现货
10 mg ¥ 417 现货
25 mg ¥ 652 现货
50 mg ¥ 840 现货
100 mg ¥ 1,263 现货
其他形式的 Toceranib Phosphate:
产品目录号及名称: Toceranib Phosphate (T7394)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR
靶点活性 PDGFRβ:5 nM (Ki), Flk-1:6 nM (Ki)
体内活性 Systolic blood pressure was significantly (P = 0.0013) higher in previously normotensive treatment dogs after initiation of treatment with toceranib phosphate (152 mmHg ± 19) compared to baseline (136 mmHg ± 14). 37% of treated dogs developed SBP ≥ 160 mmHg. The prevalence of systemic hypertension (37%) and proteinuria (21%) at baseline in treatment dogs did not differ from that of age-matched healthy controls (15% [P = 0.13] and 0% [P = 0.069], respectively)[1].
动物实验 Dogs scheduled to received toceranib phosphate treatment were divided into 2 groups based on SBP recorded at screening: dogs that were normotensive were assigned to Group 2a and dogs diagnosed with HT were assigned to Group 2b. After baseline evaluation, dogs enrolled in Group 2a received toceranib phosphate at a standard dose as previously published.2 Group 2b dogs received toceranib phosphate as described, but were also treated with standard‐of‐care treatment for HT, including amlodipine besylate (0.2–0.4 mg/kg PO q 24 hours), enalapril maleate (0.5 mg/kg PO q 12 hours), or both, initiated at the discretion of the attending veterinarian. Some dogs were treated with additional medications, including corticosteroids, at the discretion of the oncologist. All dogs were re‐evaluated on Day 14 (±3 days) at which time a UPC and blood pressure measurements were performed[1].
别名 SU11654 phosphate, PHA 291639 phosphate, 托西尼布磷酸盐
分子量 494.45
分子式 C22H28FN4O6P
CAS No. 874819-74-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: Slightly soluble

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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参考文献

1. Tjostheim S S , Stepien R L , Markovic L E , et al. Effects of Toceranib Phosphate on Systolic Blood Pressure and Proteinuria in Dogs[J]. Journal of Veterinary Internal Medicine, 2016, 30(4):951-957. 2. London C , Mathie T , Stingle N , et al. Preliminary evidence for biologic activity of toceranib phosphate (Palladia?) in solid tumours[J]. Veterinary & Comparative Oncology, 2012, 10(3):0-0.
5Z-7-Oxozeaenol Dovitinib lactate Sennoside B Nintedanib esylate AC710 ON123300 Vatalanib dihydrochloride R1530

相关化合物库

该产品包含在如下化合物库中:
抗癌上市药物库 抗癌活性化合物库 抗癌药物库 酪氨酸激酶分子库 抗肝癌化合物库 口服活性化合物库 已知活性化合物库 激酶抑制剂库 FDA上市及药典收录分子库 上市药物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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% Tween 80
% ddH2O
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Toceranib Phosphate 874819-74-6 Angiogenesis Proteases/Proteasome Tyrosine Kinase/Adaptors VEGFR Tyrosinase PDGFR c-Kit SU11654 inhibit SU11654 Phosphate SU11654 phosphate SU-11654 Toceranib SU 11654 Phosphate PHA 291639E Platelet-derived growth factor receptor PHA 291639 Phosphate PHA291639 Phosphate CD117 PHA 291639 phosphate SU-11654 Phosphate Vascular endothelial growth factor receptor 托西尼布磷酸盐 SU 11654 SCFR PHA-291639 Phosphate Inhibitor inhibitor

 

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