Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 324 | 5日内发货 | ||
5 mg | ¥ 538 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 686 | 5日内发货 |
Tirbanibulin dihydrochloride 的其他形式现货产品:
产品描述 | Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |
靶点活性 | Src HepG2:60 nM, Src PLC/PRF/5:13 nM, Src HuH7:(GI50)9 nM, Src Hep3B:26 nM |
体外活性 | Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines[1]. Tirbanibulin is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively[2]. |
体内活性 | In pre-clinical animal models of cancer, Tirbanibulin (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis[2]. |
别名 | KX-01 (dihydrochloride), KX2-391 (dihydrochloride) |
分子量 | 504.45 |
分子式 | C26H31Cl2N3O3 |
CAS No. | 1038395-65-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33.33 mg/mL (66.07 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9824 mL | 9.9118 mL | 19.8236 mL | 49.5589 mL |
5 mM | 0.3965 mL | 1.9824 mL | 3.9647 mL | 9.9118 mL | |
10 mM | 0.1982 mL | 0.9912 mL | 1.9824 mL | 4.9559 mL | |
20 mM | 0.0991 mL | 0.4956 mL | 0.9912 mL | 2.4779 mL | |
50 mM | 0.0396 mL | 0.1982 mL | 0.3965 mL | 0.9912 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tirbanibulin dihydrochloride 1038395-65-1 Angiogenesis Tyrosine Kinase/Adaptors Src Tirbanibulin Tirbanibulin Dihydrochloride KX2-391 KX 01 KX-01 KX-01 (dihydrochloride) KX01 KX2-391 (dihydrochloride) Inhibitor inhibitor inhibit