Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tianeptine (Tianeptine sodium) 是一种选择性5-HT 摄取促进剂,具有抗抑郁、抗焦虑和神经保护作用,可用于缓解疼痛的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 748 | 现货 | ||
50 mg | ¥ 1,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 407 | 现货 |
产品描述 | Tianeptine (Tianeptine sodium) is a selective 5-HT uptake facilitator in vitro and in vivo. |
体内活性 | tianeptine pretreatment upon corticosterone release and body weight loss following L-5-hydroxytryptophan (5-HTP) administration in conscious rats.?Administration of 5-HTP (20 mg/kg i.v.) increased plasma corticosterone levels to a similar extent in rats pretreated either with saline or tianeptine (10 mg/kg i.p., 60 min beforehand).?Besides, prior administration of benserazide (50 mg/kg i.p., 30 min beforehand), an inhibitor of peripheral aromatic L-amino acid decarboxylase, prevented 5-HTP-induced corticosterone release in both saline- and tianeptine-pretreated rats.?However, combined administration of benserazide and 5-HTP decreased overnight body weight in saline-, but not in tianeptine-pretreated rats.?These results suggest that tianeptine preferentially activates 5-HT reuptake in central serotonergic neurones. |
别名 | 噻萘普汀, S-1574, JNJ-39823277, Tianeptine sodium, 噻奈普汀, TPI-1062 |
分子量 | 436.95 |
分子式 | C21H25ClN2O4S |
CAS No. | 72797-41-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (22.89 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2886 mL | 11.443 mL | 22.8859 mL | 57.2148 mL |
5 mM | 0.4577 mL | 2.2886 mL | 4.5772 mL | 11.443 mL | |
10 mM | 0.2289 mL | 1.1443 mL | 2.2886 mL | 5.7215 mL | |
20 mM | 0.1144 mL | 0.5721 mL | 1.1443 mL | 2.8607 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Tianeptine 72797-41-2 GPCR/G Protein Neuroscience 5-HT Receptor S1574 JNJ 39823277 噻萘普汀 S-1574 Serotonin Receptor TPI1062 JNJ-39823277 JNJ39823277 Inhibitor inhibit Tianeptine sodium S 1574 TPI 1062 5-hydroxytryptamine Receptor 噻奈普汀 TPI-1062 inhibitor