Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Terconazole (Terazol 7) 是一种广谱抗真菌药物,用于研究阴道酵母菌感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 315 | 现货 | ||
25 mg | ¥ 497 | 现货 | ||
50 mg | ¥ 747 | 现货 | ||
100 mg | ¥ 990 | 现货 | ||
500 mg | ¥ 2,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | Terconazole (Terazol 7) is a synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Terconazole is active against Candida sp. |
体外活性 | Terconazole inhibits the growth of Candida albicans ATCC 44859 in a concentration-related manner but has modest effects at levels of 0.1 to 10 μM when the yeast is grown on media that favors the cell form. The inhibitory potency of terconazole on yeast cell viability varies with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole is markedly enhanced when the yeast is grown on Eagle minimum essential medium, which favors mycelium formation. There is a progression of changes, from loss of mycelia formation at 0.1 μM terconazole through complete necrosis at 100 μM[1]. Terconazole blocks the morphogenetic transformation from the yeast into the filamentous form at concentrations of 0.008 to 0.05 microgram/mL[2]. |
体内活性 | A 3-day once-daily intravaginal application of terconazole 0.8% is usually sufficient to provide a functional therapeutic period of 7 days due to prolonged high biologically active antifungal levels in the vagina. No side effects are observed at any concentration of terconazole[2]. |
别名 | Gyno-Terazol, Terazol 3, Terazol 7, Triaconazole, 特康唑, 曲康唑, R42470 |
分子量 | 532.46 |
分子式 | C26H31Cl2N5O3 |
CAS No. | 67915-31-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL(84.5 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8781 mL | 9.3904 mL | 18.7808 mL | 46.9519 mL |
5 mM | 0.3756 mL | 1.8781 mL | 3.7562 mL | 9.3904 mL | |
10 mM | 0.1878 mL | 0.939 mL | 1.8781 mL | 4.6952 mL | |
20 mM | 0.0939 mL | 0.4695 mL | 0.939 mL | 2.3476 mL | |
50 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.939 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Terconazole 67915-31-5 Microbiology/Virology Antifungal Antifection Gyno-Terazol inhibit Terazol 3 Inhibitor Terazol 7 Triaconazole 特康唑 Fungal 曲康唑 R-42470 R42470 R 42470 inhibitor