store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Terbinafine (TDT 067) 是念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂,Ki 值为 30 nM。它具有抗真菌感染活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 250 | 现货 | ||
100 mg | ¥ 418 | 现货 | ||
200 mg | ¥ 739 | 现货 | ||
500 mg | ¥ 1,243 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 385 | 现货 |
产品描述 | Terbinafine (TDT 067) is a synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell membrane synthesis and inhibits fungal growth. |
靶点活性 | SE:30 nM(Ki) |
体外活性 | Terbinafine (50 μM to 100 μM) inhibits only marginally the metabolism of ethoxycoumarin (CYP1A2), tolbutamide (CYP2C9), or ethynylestradiol, CsA, and cortisol. Terbinafine proves to be a potent inhibitor of the CYP2D6-mediated dextromethorphan O-demethylation and bufuralol 1-hydroxylation with IC50values of 0.2 μM and 0.25 μM, respectively. [1] Terbinafine is highly activ Aspergillus isolates (minimum inhibitory concentration [MIC] 0.01 to 2 mg/mL) with a primary fungicidal action (minimum fungicidal concentration [MFC] 0.02 to 4 mg/mL). [2] Terbinafine inhibits dextromethorphan O-demethylation with an apparent Ki ranging from 28 to 44 nM in human hepatic microsomes and averaging 22.4 nM for the heterologously expressed enzymes. [3] Terbinafine shows a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. [4] Terbinafine decreases the levels of phosphorylated extracellular signal-regulated kinase (ERK). Terbinafine might cause a decrease of MEK, which in turn up-regulates p53 through the inhibition of ERK phosphorylation, and finally causes an increase of p21expression and cell-cycle arrest. [5] |
体内活性 | Terbinafine is not only active after topical application but is extremely effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine[6]. |
别名 | Terbinex, 特比萘芬, SF 86-327, Lamisil, TDT 067 |
分子量 | 291.43 |
分子式 | C21H25N |
CAS No. | 91161-71-6 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 58 mg/mL (199.01 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 58 mg/mL (199.01 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 3.4314 mL | 17.1568 mL | 34.3136 mL | 85.7839 mL |
5 mM | 0.6863 mL | 3.4314 mL | 6.8627 mL | 17.1568 mL | |
10 mM | 0.3431 mL | 1.7157 mL | 3.4314 mL | 8.5784 mL | |
20 mM | 0.1716 mL | 0.8578 mL | 1.7157 mL | 4.2892 mL | |
50 mM | 0.0686 mL | 0.3431 mL | 0.6863 mL | 1.7157 mL | |
100 mM | 0.0343 mL | 0.1716 mL | 0.3431 mL | 0.8578 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Terbinafine 91161-71-6 Microbiology/Virology Antibacterial Antibiotic Antifungal Fungal Terbinex bacteria 特比萘芬 Candida Inhibitor squalene epoxidase Bacterial antibacterial activity SF 86-327 inhibit TDT067 TDT-067 infections Lamisil TDT 067 inhibitor