Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Teprenone (Geranylgeranylacetone) 是一种热休克蛋白诱导剂,有抗溃疡作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 122 | 现货 | ||
100 mg | ¥ 163 | 现货 | ||
500 mg | ¥ 413 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 178 | 现货 |
产品描述 | Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs). |
体外活性 | Teprenone is an HSPs inducer. Teprenone (Geranylgeranylacetone, 1 μM) significantly prevents ethanol-induced exfoliation and reduces lactate dehydrogenase (LDH) release in gastric mucosal cells. Teprenone (1 μM) gradually increases HSC70 level, and rapidly accumulates the stress-inducible HSP90, HSP70, and HSP60 concentrations within 30-60 min. Teprenone also activates the heat shock factor 1. Teprenone (0-20 µM) slightly increases human umbilical vein endothelial cell (HUVEC) viability following irradiation (IR). Teprenone (10 µM) exhibits no effects on HUVEC migration and invasion, but enhances HUVEC tube formation and wound healing both with and without IR. Teprenone (10 µM) also promotes angiogenesis via inducing VEGF and eNOS expression in HUVECs. |
体内活性 | Teprenone (200 mg/kg, p.o.) results in the accumulation of HSP70 mRNA in rats, and the accumulation is enhanced by stress addition in the mucosa of Teprenone-pretreated rats than that of vehicle-pretreated rats. Teprenone (200 mg/kg, p.o.) markedly suppresses the ulcer formation after 2- and 4-hour stress loading in rats[1]. Teprenone (200 mg/kg daily) induces HSP72 in retinal ganglion cells (RGCs) from rat retinas. Teprenone significantly reduces the loss of RGCs (evaluated after intraocular pressure (IOP) elevation), lessens optic nerve damage, decreases the number of TUNEL-positive cells in the RGC layer, and increases HSP72 in a rat model of glaucoma[2]. Teprenone (200 mg/kg, p.o.) shows protective effect on radiation-induced intestinal injury in mice. |
别名 | Tetraprenylacetone, Geranylgeranylacetone, 替普瑞酮 |
分子量 | 330.55 |
分子式 | C23H38O |
CAS No. | 6809-52-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL (96.81 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0253 mL | 15.1263 mL | 30.2526 mL | 75.6315 mL |
5 mM | 0.6051 mL | 3.0253 mL | 6.0505 mL | 15.1263 mL | |
10 mM | 0.3025 mL | 1.5126 mL | 3.0253 mL | 7.5632 mL | |
20 mM | 0.1513 mL | 0.7563 mL | 1.5126 mL | 3.7816 mL | |
50 mM | 0.0605 mL | 0.3025 mL | 0.6051 mL | 1.5126 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Teprenone 6809-52-5 Cytoskeletal Signaling Metabolism HSP Inhibitor Tetraprenylacetone Geranylgeranylacetone Heat shock proteins 替普瑞酮 inhibit inhibitor