Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Temanogrel (APD791) 是一种高度选择性的 5-HT2A 受体拮抗剂,Ki 值为 4.9 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 913 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 3,230 | 现货 | ||
25 mg | ¥ 5,660 | 现货 | ||
50 mg | ¥ 8,160 | 现货 | ||
100 mg | ¥ 11,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,280 | 现货 |
产品描述 | Temanogrel (APD791) is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). |
靶点活性 | 5-HT2A:4.9 nM (ki) |
体外活性 | Temanogrel inhibits inositol phosphate accumulation (IC50: 5.2 nM). Temanogrel shows effective inhibition of serotonin mediated amplification of ADP-stimulated human and dog platelet aggregation (IC50=8.7 and 23.1 nM, respectively). Pretreatment of aortic rings with Temanogrel prevents the vasoconstriction caused by 20 μM 5-HT in a concentration-dependent manner. Preincubation with Temanogrel also significantly inhibits the 5-HT-stimulated DNA synthesis (IC50: 13±7 nM) [1][3]. |
体内活性 | Plasma Temanogrel levels show a rapid and sustained increase, averaging 25.5±4.1, 28.7±4.6, and 31.2±4.5 ng/mL, respectively, at 10 min, 1.25 h, and 2.25 h after the start of treatment in dogs assigned to receive Temanogrel. There are no differences in heart rate or mean arterial pressure between saline-treated and Temanogrel-treated groups at any time during the experiment [3]. |
别名 | APD791 |
分子量 | 436.5 |
分子式 | C24H28N4O4 |
CAS No. | 887936-68-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (286.37 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.291 mL | 11.4548 mL | 22.9095 mL | 57.2738 mL |
5 mM | 0.4582 mL | 2.291 mL | 4.5819 mL | 11.4548 mL | |
10 mM | 0.2291 mL | 1.1455 mL | 2.291 mL | 5.7274 mL | |
20 mM | 0.1145 mL | 0.5727 mL | 1.1455 mL | 2.8637 mL | |
50 mM | 0.0458 mL | 0.2291 mL | 0.4582 mL | 1.1455 mL | |
100 mM | 0.0229 mL | 0.1145 mL | 0.2291 mL | 0.5727 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Temanogrel 887936-68-7 GPCR/G Protein Neuroscience 5-HT Receptor inhibit Serotonin Receptor Inhibitor 5-hydroxytryptamine Receptor APD 791 APD791 APD-791 inhibitor