首页 Metabolism Hydroxylase Telotristat ethyl
Telotristat ethyl
编号 T11897     别名: LX1606
CAS 1033805-22-9     分子式 C27H26ClF3N6O3     分子量 574.98
靶点: Others;
Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
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规格 库存 单价 数量
2 mg 上海现货 748.00
5 mg 上海现货 1139.00
10 mg 上海现货 2143.00
25 mg 上海现货 4286.00
50 mg 上海现货 7167.00
100 mg 上海现货 10751.00
200 mg 3-5个工作日到货 待询
1 mL * 10 mM (in DMSO) 上海现货 2233.00
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生物活性

产品描述

Telotristat ethyl is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.

靶点活性

Others,

体外活性

体内活性

Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation[1]. Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis[2].Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease.

化学信息

分子量

574.98

分子式

C27H26ClF3N6O3

CAS

1033805-22-9

溶解度

DMSO: 98.5 mg/mL (171.31mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.739 ml 8.696 ml 17.392 ml
5 mM 0.348 ml 1.739 ml 3.478 ml
10 mM 0.174 ml 0.87 ml 1.739 ml
50 mM 0.035 ml 0.174 ml 0.348 ml
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