首页 Metabolism Hydroxylase Telotristat Etiprate
Telotristat Etiprate
编号 T6044     别名: LX1606 (Hippurate), LX 1606 Hippurate, LX1606 (Hippurate) LX 1606 Hippurate
CAS 1137608-69-5     分子式 C27H26ClF3N6O3·C9H9NO3     分子量 754.15
靶点: Tryptophan hydroxylase;
Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.
选择批次  
规格 库存 单价 数量
2 mg 上海现货 530.00
5 mg 上海现货 1025.00
10 mg 上海现货 1385.00
25 mg 上海现货 2369.00
50 mg 上海现货 4085.00
1 mL * 10 mM (in DMSO) 上海现货 1155.00
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生物活性

产品描述

Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

靶点活性

Tryptophan hydroxylase,

体外活性

体内活性

Telotristat Etiprate (300 mg/kg p.o.) significantly reduces 5-HT in the gut and blood, but not brain 5-HT. Telotristat Etiprate (200 mg/kg p.o.) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis with lower expression of some genes encoding inflammation-related cytokines and chemokines in mice. [2]

动物实验

动物模型:C57BL/6 mice and C57 albino mice.

化学信息

分子量

754.15

分子式

C27H26ClF3N6O3·C9H9NO3

CAS

1137608-69-5

溶解度

DMSO: 100 mg/mL (132.59 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.326 ml 6.63 ml 13.26 ml
5 mM 0.265 ml 1.326 ml 2.652 ml
10 mM 0.133 ml 0.663 ml 1.326 ml
50 mM 0.027 ml 0.133 ml 0.265 ml
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