Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taurolidine 是一种广谱抗菌剂,用于预防中心静脉导管相关感染。它具有抗真菌和抗肿瘤作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 195 | 现货 | ||
50 mg | ¥ 297 | 现货 | ||
100 mg | ¥ 463 | 现货 | ||
200 mg | ¥ 676 | 现货 | ||
500 mg | ¥ 1,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 99 | 现货 |
产品描述 | Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity. |
体外活性 | Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1]. |
体内活性 | In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1]. |
细胞实验 | In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1]. |
动物实验 | In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1]. |
分子量 | 284.36 |
分子式 | C7H16N4O4S2 |
CAS No. | 19388-87-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56mg/mL(196.93mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5167 mL | 17.5833 mL | 35.1667 mL | 87.9167 mL |
5 mM | 0.7033 mL | 3.5167 mL | 7.0333 mL | 17.5833 mL | |
10 mM | 0.3517 mL | 1.7583 mL | 3.5167 mL | 8.7917 mL | |
20 mM | 0.1758 mL | 0.8792 mL | 1.7583 mL | 4.3958 mL | |
50 mM | 0.0703 mL | 0.3517 mL | 0.7033 mL | 1.7583 mL | |
100 mM | 0.0352 mL | 0.1758 mL | 0.3517 mL | 0.8792 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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