Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一,可诱导细胞凋亡,具有明显的抗炎和免疫调节作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 328 | 现货 | ||
50 mg | ¥ 480 | 现货 | ||
100 mg | ¥ 695 | 现货 | ||
200 mg | ¥ 987 | 现货 | ||
500 mg | ¥ 1,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 219 | 现货 |
产品描述 | Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid. |
体外活性 | Studies have suggested that taurochenodeoxycholic acid as a signaling molecule shows obvious anti-inflammatory and immune regulation properties. Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, PKC mRNA levels and activities are significantly augmented by taurochenodeoxycholic acid treatments. In addition, JNK, caspase-3 and caspase-8 mRNA expression levels and activities are increased by taurochenodeoxycholic acid. |
体内活性 | Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decrease the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduce the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice, the expression level of MMP-9 increases, while it has no significant effects on MMP2. |
别名 | Chenodeoxycholyltaurine, TCDCA, Chenyltaurine, Taurochenodeoxycholate, 12-Deoxycholyltaurine, 牛磺鹅去氧胆酸 |
分子量 | 499.7 |
分子式 | C26H45NO6S |
CAS No. | 516-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: > 22 mg/mL (44.03 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0012 mL | 10.006 mL | 20.012 mL | 50.03 mL |
5 mM | 0.4002 mL | 2.0012 mL | 4.0024 mL | 10.006 mL | |
10 mM | 0.2001 mL | 1.0006 mL | 2.0012 mL | 5.003 mL | |
20 mM | 0.1001 mL | 0.5003 mL | 1.0006 mL | 2.5015 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Taurochenodeoxycholic Acid 516-35-8 Apoptosis Metabolism Proteases/Proteasome TNF Endogenous Metabolite Caspase Chenodeoxycholyltaurine TCDCA inhibit JNK TNF-α PKC Inhibitor acid Chenyltaurine Taurochenodeoxycholate anti-inflammatory caspase-8 caspase-3 mRNA TIMP-2 immune 12-Deoxycholyltaurine regulation NR8383 bile 牛磺鹅去氧胆酸 inhibitor