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Taurochenodeoxycholic Acid

Taurochenodeoxycholic Acid

产品编号 T2A2481   CAS 516-35-8
别名: Chenodeoxycholyltaurine, TCDCA, Chenyltaurine, Taurochenodeoxycholate, 12-Deoxycholyltaurine, 牛磺鹅去氧胆酸

Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一,可诱导细胞凋亡,具有明显的抗炎和免疫调节作用。

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Taurochenodeoxycholic Acid Chemical Structure
Taurochenodeoxycholic Acid, CAS 516-35-8
规格 价格/CNY 货期 数量
25 mg ¥ 328 现货
50 mg ¥ 480 现货
100 mg ¥ 695 现货
200 mg ¥ 987 现货
500 mg ¥ 1,680 现货
1 mL * 10 mM (in DMSO) ¥ 219 现货
其他形式的 Taurochenodeoxycholic Acid:
产品目录号及名称: Taurochenodeoxycholic Acid (T2A2481)
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选择批次  
纯度: 99.86%
纯度: 99.69%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.
体外活性 Studies have suggested that taurochenodeoxycholic acid as a signaling molecule shows obvious anti-inflammatory and immune regulation properties. Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, PKC mRNA levels and activities are significantly augmented by taurochenodeoxycholic acid treatments. In addition, JNK, caspase-3 and caspase-8 mRNA expression levels and activities are increased by taurochenodeoxycholic acid.
体内活性 Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decrease the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduce the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice, the expression level of MMP-9 increases, while it has no significant effects on MMP2.
别名 Chenodeoxycholyltaurine, TCDCA, Chenyltaurine, Taurochenodeoxycholate, 12-Deoxycholyltaurine, 牛磺鹅去氧胆酸
分子量 499.7
分子式 C26H45NO6S
CAS No. 516-35-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: > 22 mg/mL (44.03 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0012 mL 10.006 mL 20.012 mL 50.03 mL
5 mM 0.4002 mL 2.0012 mL 4.0024 mL 10.006 mL
10 mM 0.2001 mL 1.0006 mL 2.0012 mL 5.003 mL
20 mM 0.1001 mL 0.5003 mL 1.0006 mL 2.5015 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15. 2. Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5. 3. Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57. 4. Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8.

文献引用

1. Qiu Q, Guo G, Guo X, et al.P53 Deficiency Accelerate Esophageal Epithelium Intestinal Metaplasia Malignancy.Biomedicines.2023, 11(3): 882.
L-Glutamic acid Alexidine dihydrochloride 3-​O-​Acetyloleanolic acid AZD5582 Carfilzomib Y-27632 dihydrochloride CGP 57380 7,8-Dihydroxyflavone

相关化合物库

该产品包含在如下化合物库中:
微生物天然产物库 抗癌药物库 抗癌上市药物库 人内源代谢化合物库 抗癌化合物库 小鼠代谢化合物库 NO PAINS 化合物库 高通量筛选天然产物库 免疫/炎症分子化合物库 NF-κB 通路分子库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Taurochenodeoxycholic Acid 516-35-8 Apoptosis Metabolism Proteases/Proteasome TNF Endogenous Metabolite Caspase Chenodeoxycholyltaurine TCDCA inhibit JNK TNF-α PKC Inhibitor acid Chenyltaurine Taurochenodeoxycholate anti-inflammatory caspase-8 caspase-3 mRNA TIMP-2 immune 12-Deoxycholyltaurine regulation NR8383 bile 牛磺鹅去氧胆酸 inhibitor

 

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