keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taltirelin (TA-0910) 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM),能够刺激细胞溶质 Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Taltirelin acetate 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 455 | 5日内发货 | ||
5 mg | ¥ 743 | 5日内发货 |
Taltirelin 的其他形式现货产品:
产品描述 | Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1]. |
靶点活性 | TRHR:910 nM (IC50) |
体内活性 | Taltirelin (TAL), in mouse models of CRF.?To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.?Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.?Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.?These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans[1]. |
别名 | TA-0910, 他替瑞林 |
分子量 | 405.41 |
分子式 | C17H23N7O5 |
CAS No. | 103300-74-9 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (74 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4666 mL | 12.3332 mL | 24.6664 mL | 61.666 mL |
5 mM | 0.4933 mL | 2.4666 mL | 4.9333 mL | 12.3332 mL | |
10 mM | 0.2467 mL | 1.2333 mL | 2.4666 mL | 6.1666 mL | |
20 mM | 0.1233 mL | 0.6167 mL | 1.2333 mL | 3.0833 mL | |
50 mM | 0.0493 mL | 0.2467 mL | 0.4933 mL | 1.2333 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Taltirelin 103300-74-9 Endocrinology/Hormones Thyroid hormone receptor(THR) Inhibitor TA0910 Thyroid Hormone Receptor TA 0910 inhibit THR TA-0910 他替瑞林 inhibitor