Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs.
产品描述 | Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. |
靶点活性 | p38β:90 nM, p38α:9 nM |
体外活性 | Talmapimod hydrochloride inhibits LPS-induced TNF-a production in human whole blood. Talmapimod hydrochloride decreases constitutive p38alpha MAPK phosphorylation of both 5T2MM and 5T33MM cells. Talmapimod hydrochloride (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells [1][2][3]. |
体内活性 | Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) dose-dependently reduced tumor growth. Talmapimod hydrochloride (10-90 mg/kg; P.o.; twice daily orally for 14 days) also dose-dependently reduced weight of the palpable tumors at termination [4]. |
别名 | SCIO-469 hydrochloride |
分子量 | 549.47 |
分子式 | C27H31Cl2FN4O3 |
CAS No. | 309915-12-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Talmapimod hydrochloride 309915-12-6 MAPK p38 MAPK SCIO 469 Hydrochloride SCIO-469 hydrochloride SCIO-469 Hydrochloride SCIO469 Hydrochloride Talmapimod Hydrochloride Inhibitor inhibitor inhibit