Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 1,060 | 5日内发货 | ||
5 mg | ¥ 1,790 | 5日内发货 | ||
10 mg | ¥ 2,730 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 5日内发货 |
产品描述 | TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1). |
靶点活性 | FFA1/GPR40 (human):6 nM (EC50) |
体外活性 | TUG-770 (Compound 22) displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes, no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein inhibition, and good permeability in the Caco-2 cell assay. |
体内活性 | Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose-dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose-lowering effect for the high doses already after 10 min and for all doses after 30 min. |
分子量 | 307.32 |
分子式 | C19H14FNO2 |
CAS No. | 1402601-82-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 100 mg/mL (325.39 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.2539 mL | 16.2697 mL | 32.5394 mL | 81.3484 mL |
5 mM | 0.6508 mL | 3.2539 mL | 6.5079 mL | 16.2697 mL | |
10 mM | 0.3254 mL | 1.627 mL | 3.2539 mL | 8.1348 mL | |
20 mM | 0.1627 mL | 0.8135 mL | 1.627 mL | 4.0674 mL | |
50 mM | 0.0651 mL | 0.3254 mL | 0.6508 mL | 1.627 mL | |
100 mM | 0.0325 mL | 0.1627 mL | 0.3254 mL | 0.8135 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TUG-770 1402601-82-4 Endocrinology/Hormones GPCR/G Protein GPR TUG 770 TUG770 Inhibitor inhibitor inhibit