Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂,与葡萄糖基碳纳米球结合时,可通过血脑屏障,对成人大脑神经发生和长期记忆功能有益。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 273 | 现货 | ||
5 mg | ¥ 637 | 现货 | ||
10 mg | ¥ 935 | 现货 | ||
25 mg | ¥ 1,560 | 现货 | ||
50 mg | ¥ 2,190 | 现货 | ||
100 mg | ¥ 2,970 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 578 | 现货 |
产品描述 | TTK21 is an activator of CBP/p300 histone acetyltransferase activity. |
体内活性 | a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter. |
分子量 | 357.75 |
分子式 | C17H15ClF3NO2 |
CAS No. | 709676-56-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (69.88 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7952 mL | 13.9762 mL | 27.9525 mL | 69.8812 mL |
5 mM | 0.559 mL | 2.7952 mL | 5.5905 mL | 13.9762 mL | |
10 mM | 0.2795 mL | 1.3976 mL | 2.7952 mL | 6.9881 mL | |
20 mM | 0.1398 mL | 0.6988 mL | 1.3976 mL | 3.4941 mL | |
50 mM | 0.0559 mL | 0.2795 mL | 0.559 mL | 1.3976 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TTK21 709676-56-2 Chromatin/Epigenetic Epigenetic Reader Domain TTK-21 HAT histone acetyltransferases neurogenesis blood–brain barrier HATs TTK 21 inhibit Histone Acetyltransferase Inhibitor long-term memory toxicity CSP CBP/p300 inhibitor