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TRi-1

产品编号 T5481 CAS 246020-68-8

TRi-1 是不可逆的胞质硫氧还蛋白还原酶1 的特异性抑制剂(IC50:12 nM)。它有抗肿瘤作用，且线粒体毒性很小。

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TRi-1, CAS 246020-68-8

规格	价格/CNY	货期
1 mg	￥ 568	现货
2 mg	￥ 837	现货
5 mg	￥ 1,490	现货
10 mg	￥ 2,320	现货
25 mg	￥ 3,830	现货
50 mg	￥ 5,390	现货
100 mg	￥ 7,490	现货
1 mL * 10 mM (in DMSO)	￥ 1,330	现货

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选择批次

纯度: 98.4%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	TRi-1 is irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1), with an IC50 of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy
靶点活性	TXNRD1:12 nM
体外活性	TRi-1, impaired growth and viability of human tumor xenografts and syngeneic mouse tumors while having little mitochondrial toxicity and being better tolerated than auranofin.
体内活性	The anticancer efficacy of TRi-1 in mouse tumor models is consistent with the idea that TXNRD1 is important for cancer cell growth in vivo
动物实验	Fox Chase male SCID mice were treated once with TRi-1 (0.7 to 10 mg/kg) or TRi-2 (0.5 to 20 mg/kg) via intravenous injections, and mouse health status was observed for up to 72 hours. For repeateddose toxicity studies with tumor-bearing animals, mice were first inoculated with 1*10^6 FaDu cells in phosphate-buffered saline at a preshaved region located at the anterior lateral thoracic wall . After 13 days of growth, tumors were measured by calipers, and treatments were initiated. Mice were injected with TRi-1 (10 mg/kg), TRi-2 (15 mg/kg), auranofin (10 mg/kg), or vehicle a total of nine times during a 5-day span via intravenous tail injection. Upon the final day of dosing, injections were performed subcutaneously due to hematomas in several of the mice at the tail injection site. Mouse health status was monitored daily, weight was measured, and tumor volume was recorded from caliper measurements.

分子量	328.73
分子式	C12H9ClN2O5S
CAS No.	246020-68-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 62.5 mg/mL (190.13 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.042 mL	15.2101 mL	30.4201 mL	76.0503 mL
	5 mM	0.6084 mL	3.042 mL	6.084 mL	15.2101 mL
	10 mM	0.3042 mL	1.521 mL	3.042 mL	7.605 mL
	20 mM	0.1521 mL	0.7605 mL	1.521 mL	3.8025 mL
	50 mM	0.0608 mL	0.3042 mL	0.6084 mL	1.521 mL
	100 mM	0.0304 mL	0.1521 mL	0.3042 mL	0.7605 mL

计算器

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参考文献

1. Stafford WC, et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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