Powder: -20°C for 3 years | In solvent: -80°C for 1 year
THPP-1 是一种 SGC 推荐的化学探针, 是一种口服具有活性的磷酸二酯酶10A 抑制剂,其对人和大鼠的Ki 分别为 1 nM 和 1.3 nM。它的药理学特性良好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 315 | 现货 | ||
2 mg | ¥ 453 | 现货 | ||
5 mg | ¥ 738 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,660 | 现货 | ||
50 mg | ¥ 3,930 | 现货 | ||
100 mg | ¥ 5,730 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 756 | 现货 |
产品描述 | THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). |
靶点活性 | PDE10A:1-1.3 nM |
体内活性 | Consistent with rodent data, both THPP-1 and risperidone significantly attenuated the stimulant effects in SIMA when administered alone, though some differences were noted.?Combination therapy with a low dose of risperidone produced significantly more robust effects.?THPP-1 and risperidone also produced a marked reduction of wake cycle time and gamma frequency power in EEG.?However, THPP-1 differed from risperidone by reducing spectral power of lower frequencies[1]. |
分子量 | 464.9 |
分子式 | C23H21ClN6O3 |
CAS No. | 1257051-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (66.68 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.151 mL | 10.755 mL | 21.51 mL | 53.775 mL |
5 mM | 0.4302 mL | 2.151 mL | 4.302 mL | 10.755 mL | |
10 mM | 0.2151 mL | 1.0755 mL | 2.151 mL | 5.3775 mL | |
20 mM | 0.1076 mL | 0.5378 mL | 1.0755 mL | 2.6888 mL | |
50 mM | 0.043 mL | 0.2151 mL | 0.4302 mL | 1.0755 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
THPP-1 1257051-63-0 Metabolism PDE PDE10A SIMA object recognition Phosphodiesterase (PDE) Inhibitor inhibit THPP 1 THPP1 novel inhibitor