Powder: -20°C for 3 years | In solvent: -80°C for 1 year
THIQ 是一种选择性黑皮质素 4 受体 (MC4R) 激动剂,对 hMC4R 和 rMC4R 的 IC50 分别为 1.2 和 0.6 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 397 | 现货 | ||
2 mg | ¥ 549 | 现货 | ||
5 mg | ¥ 828 | 现货 | ||
10 mg | ¥ 1,320 | 现货 | ||
25 mg | ¥ 2,650 | 现货 | ||
50 mg | ¥ 3,980 | 现货 | ||
100 mg | ¥ 5,670 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,070 | 现货 |
产品描述 | THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). |
靶点活性 | MC4R (rat):0.6 nM, MC4R (human):1.2 nM |
体外活性 | THIQ,?a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines.?THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells.?In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y). |
分子量 | 589.17 |
分子式 | C33H41ClN6O2 |
CAS No. | 312637-48-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL(415.84 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6973 mL | 8.4865 mL | 16.973 mL | 42.4326 mL |
5 mM | 0.3395 mL | 1.6973 mL | 3.3946 mL | 8.4865 mL | |
10 mM | 0.1697 mL | 0.8487 mL | 1.6973 mL | 4.2433 mL | |
20 mM | 0.0849 mL | 0.4243 mL | 0.8487 mL | 2.1216 mL | |
50 mM | 0.0339 mL | 0.1697 mL | 0.3395 mL | 0.8487 mL | |
100 mM | 0.017 mL | 0.0849 mL | 0.1697 mL | 0.4243 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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