keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tetrahydropiperine (Cosmoperine) 是胡椒碱的环己基类似物,也是一种天然芳基戊酰胺,从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH;IC50=23 µM)具有抑制作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 413 | 现货 | ||
50 mg | ¥ 588 | 现货 | ||
100 mg | ¥ 882 | 现货 | ||
500 mg | ¥ 2,180 | 现货 |
产品描述 | Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. |
靶点活性 | MOCD:25 µM, TRPV1:6.3 µM , CYP450:23 µM |
体内活性 | TETRAHYDROPIPERINE is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 μM)[1]. It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 μM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 μM) in rat liver microsomes[2].Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 μl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR)[3]. |
动物实验 | The test compounds were PIP [5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylpiperidine], tetrahydropiperine [THP, 5-(3,4-methylenedioxyphenyl)-pentanoylpiperidine], a cyclohexyl analogue of piperine [CHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylcyclohexylamine], and reduced CHP [rCHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentanoylcyclohexylamine].?Sparsely pigmented, HRA/Skh-II mice were randomized to receive topical treatment with test compounds or vehicle twice a day for five days a week, with or without ultraviolet (UV) irradiation on 3 days a week.?Treatment was either continuous or interrupted to evaluate fading and repigmentation.?Skin inflammation and pigmentation were evaluated regularly during treatment.?DOPA+ melanocytes were determined histologically at the termination of treatment[3]. |
别名 | 四氢胡椒碱, Cosmoperine |
分子量 | 289.37 |
分子式 | C17H23NO3 |
CAS No. | 23434-88-0 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 57 mg/mL (196.97 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4558 mL | 17.2789 mL | 34.5578 mL | 86.3946 mL |
5 mM | 0.6912 mL | 3.4558 mL | 6.9116 mL | 17.2789 mL | |
10 mM | 0.3456 mL | 1.7279 mL | 3.4558 mL | 8.6395 mL | |
20 mM | 0.1728 mL | 0.8639 mL | 1.7279 mL | 4.3197 mL | |
50 mM | 0.0691 mL | 0.3456 mL | 0.6912 mL | 1.7279 mL | |
100 mM | 0.0346 mL | 0.1728 mL | 0.3456 mL | 0.8639 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TETRAHYDROPIPERINE 23434-88-0 Membrane transporter/Ion channel Metabolism P450 TRP/TRPV Channel Inhibitor Cytochrome P450 四氢胡椒碱 AHH CYP arylhydrocarbon CYP1A1 CYPs Cosmoperine Piperine aryl pentanamide hydroxylase inhibit inhibitor