Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 13,500 | 2-4周 | ||
50 mg | ¥ 18,300 | 2-4周 | ||
100 mg | ¥ 23,500 | 2-4周 |
产品描述 | T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM). |
靶点活性 | LSD1:22 nM |
体外活性 | The levels of H3K4 methylation enhanced by T-448, and increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction. |
体内活性 | T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction. T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg. |
分子量 | 772.94 |
分子式 | C38H44N8O6S2 |
CAS No. | 1597426-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (43.13 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.2938 mL | 6.4688 mL | 12.9376 mL | 32.344 mL |
5 mM | 0.2588 mL | 1.2938 mL | 2.5875 mL | 6.4688 mL | |
10 mM | 0.1294 mL | 0.6469 mL | 1.2938 mL | 3.2344 mL | |
20 mM | 0.0647 mL | 0.3234 mL | 0.6469 mL | 1.6172 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
T-448 1597426-53-3 Chromatin/Epigenetic Histone Demethylase T 448 T448 Inhibitor inhibitor inhibit