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Sulfometuron-methyl

Sulfometuron-methyl

产品编号 T19761   CAS 74222-97-2
别名: DXP 5648, DXP-5648, 甲嘧磺隆, DXP5648

Sulfometuron-methyl (DXP-5648) 是一种除草剂,也是一种活性抗菌剂。它是乙酰乳酸合酶 II 的有效抑制剂,因此具有抗菌特性。

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Sulfometuron-methyl Chemical Structure
Sulfometuron-methyl, CAS 74222-97-2
规格 价格/CNY 货期 数量
5 mg ¥ 432 现货
10 mg ¥ 617 现货
25 mg ¥ 1,112 现货
50 mg ¥ 1,588 现货
100 mg ¥ 2,269 现货
1 mL * 10 mM (in DMSO) ¥ 397 现货
产品目录号及名称: Sulfometuron-methyl (T19761)
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Sulfometuron-methyl (DXP-5648) is a herbicide and also is an active antibacterial agent. It is an effective inhibitor of acetolactate synthase II and thus shows antibacterial properties.
体外活性 The sulfonylurea herbicide sulfometuron methyl inhibits the growth of several bacterial species. In the presence of L-valine, sulfometuron methyl inhibits Salmonella typhimurium, this inhibition can be reversed by L-isoleucine. Reversal of growth retardation by L-isoleucine, accumulation of guanosine 5'-diphosphate 3'-diphosphate (magic spot), and relA mutant hypersensitivity suggest sulfometuron methyl interference with branched-chain amino acid biosynthesis. Growth inhibition of S. typhimurium is mediated by sulfometuron methyl's inhibition of acetolactate synthase, the first common enzyme in the branched-chain amino acid biosynthetic pathway. Sulfometuron methyl exhibits slow-binding inhibition of acetolactate synthase isozyme II from S. typhimurium with an initial Ki of 660 +/- 60 nM and a final, steady-state Ki of 65 +/- 25 nM. Inhibition of acetolactate synthase by sulfometuron methyl is substantially more rapid (10 times) in the presence of pyruvate with a maximal first-order rate constant for conversion from initial to final steady-state inhibition of 0.25 +/- 0.07 min-1 (minimal half-time of 2.8 min). Mutants of S. typhimurium able to grow in the presence of sulfometuron methyl were obtained. They have acetolactate synthase activity that is insensitive to sulfometuron methyl because of mutations in or near ilvG, the structural gene for acetolactate synthase isozyme II[2].
别名 DXP 5648, DXP-5648, 甲嘧磺隆, DXP5648
分子量 364.38
分子式 C15H16N4O5S
CAS No. 74222-97-2

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 18.33 mg/ml (50.31 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7444 mL 13.7219 mL 27.4439 mL 68.6097 mL
5 mM 0.5489 mL 2.7444 mL 5.4888 mL 13.7219 mL
10 mM 0.2744 mL 1.3722 mL 2.7444 mL 6.861 mL
20 mM 0.1372 mL 0.6861 mL 1.3722 mL 3.4305 mL
50 mM 0.0549 mL 0.2744 mL 0.5489 mL 1.3722 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. LaRossa RA, Smulski DR. ilvB-encoded acetolactate synthase is resistant to the herbicide sulfometuron methyl. J Bacteriol. 1984 Oct;160(1):391-4. PubMed PMID: 6090425; PubMed Central PMCID: PMC214730. 2. LaRossa RA, Schloss JV. The sulfonylurea herbicide sulfometuron methyl is an extremely potent and selective inhibitor of acetolactate synthase in Salmonella typhimurium. J Biol Chem. 1984 Jul 25;259(14):8753-7. PubMed PMID: 6378902. 3. Michael JL. Environmental fate and impacts of sulfometuron on watersheds in the southern United States. J Environ Qual. 2003 Mar-Apr;32(2):456-65. PubMed PMID: 12708668. 4. Yadav N, McDevitt RE, Benard S, Falco SC. Single amino acid substitutions in the enzyme acetolactate synthase confer resistance to the herbicide sulfometuron methyl. Proc Natl Acad Sci U S A. 1986 Jun;83(12):4418-22. PubMed PMID: 16593715; PubMed Central PMCID: PMC323744.
Sulfacetamide sodium monohydrate Cloxiquine Ampicillin Doxycycline Brodimoprim MOSLOFLAVONE N-octanoyl-L-Homoserine lactone 3,4-Dihydroxy-2-methoxyxanthone

相关化合物库

该产品包含在如下化合物库中:
人代谢物化合物库 抑制剂库 NO PAINS 化合物库 已知活性化合物库 抗菌活性库 抗感染化合物库 经典已知活性库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Sulfometuron-methyl 74222-97-2 Microbiology/Virology Antibacterial DXP 5648 DXP-5648 甲嘧磺隆 Sulfometuronmethyl DXP5648 Sulfometuron methyl Inhibitor inhibitor inhibit

 

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