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Sulfasalazine

Sulfasalazine

产品编号 T0907   CAS 599-79-1
别名: 柳氮磺吡啶, NSC 667219, Azulfidine

Sulfasalazine (Azulfidine) 是一种合成的水杨酸衍生物,对含有弹性蛋白的结缔组织具有亲和力,并配制成前药。

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Sulfasalazine Chemical Structure
Sulfasalazine, CAS 599-79-1
规格 价格/CNY 货期 数量
500 mg ¥ 333 现货
1 g ¥ 418 现货
5 g ¥ 671 现货
1 mL * 10 mM (in DMSO) ¥ 418 现货
产品目录号及名称: Sulfasalazine (T0907)
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纯度: 99.28%
纯度: 98.73%
纯度: 98.05%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Sulfasalazine (Azulfidine) is a synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug
体外活性 Sulfasalazine, like methotrexate, enhances adenosine release at an inflamed site and that adenosine diminishes inflammation via occupancy of A2 receptors on inflammatory cells. [1] Sulfasalazine treatment for 4 hours inhibits kappaB-dependent transcription with an IC50 value of approximately 0.625 mM. Sulfasalazine (2.5 mM) results in cell death of T-lymphocytes in a dose- and time-dependent manner. Sulfasalazine but not 5ASA or sulfapyridine, strongly inhibits NF-kappaB activation and potently induces apoptosis in T-lymphocytes. [2] Sulfasalazine is cleaved into sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine) by colonic bacteria, and the latter, too, is reported to suppress NF-kappaB activity. Sulfasalazine but not its cleaved form 5-ASA causes a dose-dependent inhibition of glioma growth, this effect is entirely attributable to the inhibition of cystine uptake via the system x(c)(-) cystine-glutamate transporter. Sulfasalazine inhibits cystine uptake causing a chronic depletion of intracellular GSH and consequently compromised cellular redox defense which stymied tumor growth. [3]
体内活性 Sulfasalazine markedly decreases the number of leukocytes that accumulated in the inflamed (carrageenan, 2 mg/ml) air pouch in the murine air pouch model of inflammation. Sulfasalazine treatment promotes a marked increase in splenocyte 5-aminoimidazole-4-carboxamidoribonucleotide (AICAR) concentration, which is consistent with the in vitro observation that sulfasalazine inhibits AICAR transformylase. [1]
细胞实验 Sulfasalazine is dissolved in culture medium. SW620 cells are grown in Dulbecco's modified Eagle medium, supplemented with 10% heat-inactivated FCS, 2 mmol/liter glutamine, and 1% (wt/vol) penicillin/streptomycin. SW620 cells are transfected with the 3xIgkBLuc reporter construct. After 18 h, cells are incubated with either medium alone or with sulfasalazine (0.1, 0.2, 0.5, 1, 2, 5 mM) before stimulation with TNFα, LPS, or PMA. Luciferase assay is performed[1].
别名 柳氮磺吡啶, NSC 667219, Azulfidine
分子量 398.39
分子式 C18H14N4O5S
CAS No. 599-79-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 200 mg/mL (502.02 mM), Sonification/heating is recommended.

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5101 mL 12.5505 mL 25.101 mL 62.7526 mL
5 mM 0.502 mL 2.5101 mL 5.0202 mL 12.5505 mL
10 mM 0.251 mL 1.2551 mL 2.5101 mL 6.2753 mL
20 mM 0.1255 mL 0.6275 mL 1.2551 mL 3.1376 mL
50 mM 0.0502 mL 0.251 mL 0.502 mL 1.2551 mL
100 mM 0.0251 mL 0.1255 mL 0.251 mL 0.6275 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Gadangi P, et al. J Immunol,1996, 156(5), 1937-1941. 2. Liptay S, et al. Br J Pharmacol,1999, 128(7), 1361-1369. 3. Chung WJ, et al. J Neurochem,2009, 110(1), 182-193. 4. Wang Y, Wang S, Xin Y, et al. Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis[J]. Life Sciences. 2021: 119551. 5. Lu Y, Yang Q, Su Y, et al. MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma[J]. Cell Death & Disease. 2021, 12(6): 1-14.

文献引用

1. Ma R, Fang L, Chen L, et al. Ferroptotic stress promotes macrophages against intracellular bacteria. Theranostics. 2022, 12(5): 2266 2. Lu Y, Yang Q, Su Y, et al. MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma. Cell Death & Disease. 2021, 12(6): 1-14. 3. Ni H, Ruan G, Sun C, et al. Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis. Environmental Toxicology. 2021 4. Wang Y, Wang S, Xin Y, et al. Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis. Life Sciences. 2021: 119551.
ML385 Deferoxamine Mesylate Butylhydroxyanisole Erastin MMRi62 Rosiglitazone maleate Lapatinib RSL3

相关化合物库

该产品包含在如下化合物库中:
抗癌临床化合物库 抗癌药物库 抗癌上市药物库 人代谢物化合物库 儿童药物库 转录因子库 免疫/炎症分子化合物库 抗心血管疾病化合物库 抗卵巢癌化合物库 抗菌活性库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Sulfasalazine 599-79-1 Apoptosis Autophagy Immunology/Inflammation Microbiology/Virology Neuroscience NF-Κb Ferroptosis NF-κB COX Antibacterial Antibiotic Nuclear factor-κB 柳氮磺吡啶 Inhibitor NSC 667219 Nuclear factor-kappaB Bacterial inhibit NSC667219 NSC-667219 Azulfidine inhibitor

 

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