Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) 是一种可逆的 COX 拮抗剂,具有抗炎、抗水肿和解热特性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 428 | 现货 | ||
2 mg | ¥ 617 | 现货 | ||
5 mg | ¥ 947 | 现货 | ||
10 mg | ¥ 1,660 | 现货 | ||
25 mg | ¥ 3,230 | 现货 | ||
50 mg | ¥ 4,790 | 现货 | ||
100 mg | ¥ 6,850 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 947 | 现货 |
产品描述 | Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema, and antipyretic properties. |
体外活性 | Sudoxicam binds covalently to NADPH-dependent human liver microsomes. When glutathione (GSH) was added to the microsomal incubation, about half of the covalent binding of sudoxicam was blocked by glutathione[1]. |
体内活性 | Sudoxicam (0.1 mg/kg, p.o) significantly inhibits edema formation. In rats, Sudoxicam (1, 3.3 and 10 mg/kg; orally) effectively reduces plasma inflammation units, decreases the inflamed hind-paws swelling and restores toward normal the daily gain in body weight. Sudoxicam (3.3 mg/kg, i.p.) counteracts the pyrexia induced by the intraperitoneal injection of typhoid/paratyphoid vaccine and maintains body temperature. In the guinea pig, Sudoxicam inhibits the erythema caused by ultraviolet irradiation. The plasma half-life of Sudoxicam is 8, 13 and hours for monkey, rat and dog[2]. |
别名 | 舒多昔康, 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide |
分子量 | 337.37 |
分子式 | C13H11N3O4S2 |
CAS No. | 34042-85-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (237.13 mM), ultrasonic and warming and heat to 80°C
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9641 mL | 14.8205 mL | 29.641 mL | 74.1026 mL |
5 mM | 0.5928 mL | 2.9641 mL | 5.9282 mL | 14.8205 mL | |
10 mM | 0.2964 mL | 1.4821 mL | 2.9641 mL | 7.4103 mL | |
20 mM | 0.1482 mL | 0.741 mL | 1.4821 mL | 3.7051 mL | |
50 mM | 0.0593 mL | 0.2964 mL | 0.5928 mL | 1.4821 mL | |
100 mM | 0.0296 mL | 0.1482 mL | 0.2964 mL | 0.741 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sudoxicam 34042-85-8 Immunology/Inflammation Neuroscience COX 舒多昔康 4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide Inhibitor inhibitor inhibit