Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sucralfate (Sucrose octasulfate–aluminum complex) 是一种口服活性胃保护剂。它抑制消化性活性,并与黏膜损伤时暴露的带负电荷的上皮下蛋白结合,形成一层粘性层,保护血管床和增殖区。它可用于预防和治疗胃肠道疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 197 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 150 | 现货 |
产品描述 | Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. |
体外活性 | Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I[3]. It protects RGMl cells from acid- and pepsin-induced damage[4]. |
体内活性 | The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region[2]. |
细胞实验 | Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO2, in air for 0.5-4 h. In some cases, cells are treated with 10-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate. (Only for Reference) |
别名 | 硫糖铝, Sucrose octasulfate–aluminum complex |
分子量 | 2086.75 |
分子式 | C12H54Al16O75S8 |
CAS No. | 54182-58-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20.87 mg/ml (10 mM)
H2O: 0.4 mg/mL (0.20 mM), ultrasonic and adjust pH to 2 with HCl
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.4792 mL | 2.3961 mL | 4.7921 mL | 11.9804 mL |
5 mM | 0.0958 mL | 0.4792 mL | 0.9584 mL | 2.3961 mL | |
10 mM | 0.0479 mL | 0.2396 mL | 0.4792 mL | 1.198 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sucralfate 54182-58-0 Angiogenesis GPCR/G Protein Immunology/Inflammation Microbiology/Virology Others Tyrosine Kinase/Adaptors FGFR Antibacterial Prostaglandin Receptor Bacterial Inhibitor inhibit Sucrose octasulfate-aluminum complex 硫糖铝 Sucrose octasulfate–aluminum complex inhibitor