Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Spinorphin 是一种脑非肽降解酶抑制剂,能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶和脑非肽酶。它可用于研究疼痛的缓解。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,210 | 现货 | ||
5 mg | ¥ 2,480 | 现货 | ||
10 mg | ¥ 3,980 | 现货 | ||
25 mg | ¥ 6,370 | 现货 | ||
50 mg | ¥ 8,730 | 现货 | ||
100 mg | ¥ 11,700 | 现货 |
产品描述 | Spinorphin is a heptapeptide, and is a potent enkephalin-degrading enzymes inhibitor. |
体外活性 | Spinorphin inhibited cytoplasmic Ca(2+) ([Ca(2+)]i) transients, evoked by depolarization and capsaicin selectively in medium and small cultured rat DRG neurons.?Spinorphin (10-300 M) inhibited the Ca(2+) signals in concentration dependant manner in small- and medium diameter DRG neurons.?Capsaicin produced [Ca(2+)]i responses only in small- and medium-sized DRG neurons, and pre-treatment with spinorphin significantly attenuated these [Ca(2+)]i responses[1]. |
体内活性 | Spinorphin significantly inhibited the functions of polymorphonuclear neutrophils (PMNs) by suppressing the binding of fMLF to its receptor on PMNs. Further, this inhibitor suppressed the carrageenan-induced accumulation of PMN in mouse air pouches after intravenous administration. These results indicate that spinorphin may be an endogenous anti-inflammatory regulator. The possible role of spinorphin and its analog as regulators in pain and inflammation will be discussed[2]. |
分子量 | 877 |
分子式 | C45H64N8O10 |
CAS No. | 137201-62-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.1403 mL | 5.7013 mL | 11.4025 mL | 28.5063 mL |
5 mM | 0.2281 mL | 1.1403 mL | 2.2805 mL | 5.7013 mL | |
10 mM | 0.114 mL | 0.5701 mL | 1.1403 mL | 2.8506 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Spinorphin 137201-62-8 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor inhibit Inhibitor inhibitor