Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sofalcone (SU-88) 可诱导血红素加氧酶-1在胃肠上皮中的表达,是一种抗胃溃疡剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 415 | 现货 | ||
500 mg | ¥ 831 | 现货 | ||
1 g | ¥ 1,366 | 现货 |
产品描述 | Sofalcone (SU-88), a gastric antiulcer agent in clinical use, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
体外活性 | Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression than the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis shows that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs. |
细胞实验 | Primary HUVECs are seeded at 60?000 cells per well and incubated at 37°C for 14 to 16 hours to allow tube formation. Cells are then cultured in the presence of either TNF-α (10 ng/mL) alone, with both TNF-α (10 ng/mL) and Sofalcone 50 μM, or control media for 8 to 12 hours. Tube formation is assessed, and images are captured using microscope at ×4 magnification. |
别名 | 索法酮, SU-88 |
分子量 | 450.52 |
分子式 | C27H30O6 |
CAS No. | 64506-49-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (110.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2197 mL | 11.0983 mL | 22.1966 mL | 55.4914 mL |
5 mM | 0.4439 mL | 2.2197 mL | 4.4393 mL | 11.0983 mL | |
10 mM | 0.222 mL | 1.1098 mL | 2.2197 mL | 5.5491 mL | |
20 mM | 0.111 mL | 0.5549 mL | 1.1098 mL | 2.7746 mL | |
50 mM | 0.0444 mL | 0.222 mL | 0.4439 mL | 1.1098 mL | |
100 mM | 0.0222 mL | 0.111 mL | 0.222 mL | 0.5549 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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