首页 GPCR/G Protein Histamine Receptor Sodium butanoate
Sodium butanoate
编号 T1393     别名: Butanoic acid sodium salt, Sodium Butyrate
CAS 156-54-7     分子式 C4H7NaO2     分子量 110.09
靶点: H1 receptor;
Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).
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规格 库存 单价 数量
500 mg 上海现货 280.00
1 g 上海现货 350.00
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生物活性

产品描述

Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

靶点活性

H1 receptor,

体外活性

在结肠粘膜中,Sodium butyrate能够产生抗炎和抗癌作用,降低氧化应激,从而抑制结肠癌细胞的生长。在RG / C2和AA / Cl腺瘤细胞系中,Sodium butyrate能够诱导细胞产生凋亡。

体内活性

Sodium butyrate能够增加组蛋白和特异性蛋白-1乙酰化,同时抑制3-硝基丙酸产生神经毒性.在亨廷顿氏病的R6 /2转基因小鼠模型中,Sodium butyrate能够延缓后遗症的发作和延长生存周期.

细胞实验

Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 µL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 µL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 µL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

动物实验

动物模型:rat

化学信息

分子量

110.09

分子式

C4H7NaO2

CAS

156-54-7

溶解度

H2O: 100 mg/mL (908.35 mM), Need ultrasonic

DMSO: 1 mg/mL (9.08 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 9.083 ml 45.417 ml 90.835 ml
5 mM 1.817 ml 9.083 ml 18.167 ml
10 mM 0.908 ml 4.542 ml 9.083 ml
50 mM 0.182 ml 0.908 ml 1.817 ml
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