Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sertindole (Lu 23-174) 是一种非典型抗精神病药,可与多巴胺 D2 受体和血清素受体亚型 5-HT1D、5-HT2A 和 5-HT2C 结合,Kd 值分别为 2.7、20、0.14 和 6 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 349 | 现货 | ||
10 mg | ¥ 497 | 现货 | ||
25 mg | ¥ 1,130 | 现货 | ||
50 mg | ¥ 1,980 | 现货 | ||
100 mg | ¥ 3,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 428 | 现货 |
产品描述 | Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
体内活性 | In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3]. |
动物实验 | Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1]. |
别名 | Lu 23-174, 舍吲哚 |
分子量 | 440.94 |
分子式 | C24H26ClFN4O |
CAS No. | 106516-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.39 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2679 mL | 11.3394 mL | 22.6788 mL | 56.6971 mL |
5 mM | 0.4536 mL | 2.2679 mL | 4.5358 mL | 11.3394 mL | |
10 mM | 0.2268 mL | 1.1339 mL | 2.2679 mL | 5.6697 mL | |
20 mM | 0.1134 mL | 0.567 mL | 1.1339 mL | 2.8349 mL | |
50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1339 mL | |
100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.567 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sertindole 106516-24-9 Autophagy GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Adrenergic Receptor Jurkat A172 MCF-7 anti-proliferative activity U118-MG MKN45 Bel-7402 SW480 COLO205 SUM159 NCI-H661 SW620 Beta Receptor Lu 23-174 CCRF-CEM HCT-15 SGC-7901 801-D Serotonin Receptor 5-hydroxytryptamine Receptor NCI-H460 NCI-H446 U87-MG BGC-823 HT-29 K562 inhibit U251 舍吲哚 MCF-10A T47D AGS antipsychotic activity A549 HepG2 Inhibitor inhibitor