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Sertaconazole nitrate

Sertaconazole nitrate

产品编号 T6665   CAS 99592-39-9
别名: FI-7045, Ginedermofix, FI7056, Ertaczo, 硝酸舍他康唑

Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药,可用于治疗浅表皮肤和粘膜感染。

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Sertaconazole nitrate Chemical Structure
Sertaconazole nitrate, CAS 99592-39-9
规格 价格/CNY 货期 数量
10 mg ¥ 278 现货
25 mg ¥ 449 现货
50 mg ¥ 629 现货
100 mg ¥ 967 待询
200 mg ¥ 1,430 待询
1 mL * 10 mM (in DMSO) ¥ 276 现货
其他形式的 Sertaconazole nitrate:
产品目录号及名称: Sertaconazole nitrate (T6665)
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纯度: 98.66%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections.
靶点活性 proliferation of human lymphocytes:4 μg/mL
体外活性 Sertaconazole nitrate reduces the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation in a dose-dependent fashion. Sertaconazole nitrate is found to inhibit the proliferation of stimulated human lymphocytes with IC50 of 4 μg/mL. [1] Sertaconazole nitrate inhibits ergosterol synthesis by blockade of the P450-dependent enzyme pathway that catalyzes the methylation of lanosterol to ergosterol, thus inhibits fungal cell growth. Sertaconazole nitrate binds directly to nonsterol lipids in the membrane, which interferes with the regulation of the permeability of fungal cell membranes, thus induces fungal cell death. [2] Sertaconazole nitrate (< 100 μg/mL) activates p38 MAP kinase and Hsp27 in keratinocytes. Sertaconazole induces (< 2 μg/mL) COX-2 protein expression and PGE2 production in keratinocytes, which dependent on p38 activation. PGE2 is involved in sertaconazole (1 μg/mL)-mediated suppression of cytokine production in keratinocytes and PBMCs. [3]
体内活性 The mean ear weight of Tetradecanoyl phorbol acetate (TPA)-challenged murine treated with sertaconazole nitrate (1%) is 7.23 mg compared with 14.7 mg for controls, indicating a statistically significant reduction in irritant dermatitis. Sertaconazole nitrate 1% elicits a significant reduction in Resiniferatoxin-induced ear edema when compared with controls in CD-1 mice. Topical treatment with sertaconazole nitrate 1% significantly inhibits contact hypersensitivity and decreases the content of the pro-inflammatory cytokines TNFα, IL-2, and IFNγ in oxazolone exposed murine skin. [1] Clinical trials with sertaconazole nitrate cream 2% show efficacy in the treatment of superficial cutaneous fungal infections. [2] Sertaconazole reduces inflammation via inducing PGE2 production and the COX-2 inhibitor blocks sertaconazole from exerting its anti-inflammatory effects in a mouse model of TPA-induced ear edema. [3] The dermal administration of sertaconazole nitrate (2%) to rats, in which edema is induced by application of croton oil in the external ear, induced a 39.8% reduction of edema. [4]
别名 FI-7045, Ginedermofix, FI7056, Ertaczo, 硝酸舍他康唑
分子量 500.78
分子式 C20H15Cl3N2OS·HNO3
CAS No. 99592-39-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 93 mg/mL (185.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9969 mL 9.9844 mL 19.9688 mL 49.9221 mL
5 mM 0.3994 mL 1.9969 mL 3.9938 mL 9.9844 mL
10 mM 0.1997 mL 0.9984 mL 1.9969 mL 4.9922 mL
20 mM 0.0998 mL 0.4992 mL 0.9984 mL 2.4961 mL
50 mM 0.0399 mL 0.1997 mL 0.3994 mL 0.9984 mL
100 mM 0.02 mL 0.0998 mL 0.1997 mL 0.4992 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Liebel F, et al. Arch Dermatol Res, 2006, 298(4), 191-199. 2. Pfaller MA, et al. Diagn Microbiol Infect Dis, 2006, 56(2), 147-152. 3. Sur R, et al. J Invest Dermatol, 2008, 128(2), 336-344. 4. Agut J, et al. Methods Find Exp Clin Pharmacol, 1996, 18(4), 233-234.
CCR-11 Imidazoleacetic acid hydrochloride Terbutaline Sulfate Aminothiazole Sulfasalazine Clioquinol Danofloxacin Fumitremorgin C

相关化合物库

该产品包含在如下化合物库中:
抗生素库 经典已知活性库 上市药物库 药物功能重定位化合物库 抗抑郁症化合物库 抗感染化合物库 NO PAINS 化合物库 免疫/炎症分子化合物库 已知活性化合物库 FDA 上市药物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Sertaconazole nitrate 99592-39-9 Microbiology/Virology Antibiotic Antifungal COX-2 FI-7056 Inhibitor inhibit MCF-7 HaCaT Candida HeLa FI-7045 Ginedermofix FI7056 Ertaczo p38 MAPK A549 PGE2 Sertaconazole HEK-293 Apoptosis FI 7045 FI 7056 硝酸舍他康唑 Fungal Microtubule/Tubulin FI7045 Sertaconazole Nitrate Autophagy inhibitor

 

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