Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药,可用于治疗浅表皮肤和粘膜感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 278 | 现货 | ||
25 mg | ¥ 449 | 现货 | ||
50 mg | ¥ 629 | 现货 | ||
100 mg | ¥ 967 | 待询 | ||
200 mg | ¥ 1,430 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 276 | 现货 |
产品描述 | Sertaconazole nitrate (FI-7045), a topical broad-spectrum antifungal, is developed to supply an additional agent for the treatment of superficial cutaneous and mucosal infections. |
靶点活性 | proliferation of human lymphocytes:4 μg/mL |
体外活性 | Sertaconazole nitrate reduces the release of cytokines from activated lymphocytes and mitigated inflammation in animal models of irritant contact dermatitis and neurogenic inflammation in a dose-dependent fashion. Sertaconazole nitrate is found to inhibit the proliferation of stimulated human lymphocytes with IC50 of 4 μg/mL. [1] Sertaconazole nitrate inhibits ergosterol synthesis by blockade of the P450-dependent enzyme pathway that catalyzes the methylation of lanosterol to ergosterol, thus inhibits fungal cell growth. Sertaconazole nitrate binds directly to nonsterol lipids in the membrane, which interferes with the regulation of the permeability of fungal cell membranes, thus induces fungal cell death. [2] Sertaconazole nitrate (< 100 μg/mL) activates p38 MAP kinase and Hsp27 in keratinocytes. Sertaconazole induces (< 2 μg/mL) COX-2 protein expression and PGE2 production in keratinocytes, which dependent on p38 activation. PGE2 is involved in sertaconazole (1 μg/mL)-mediated suppression of cytokine production in keratinocytes and PBMCs. [3] |
体内活性 | The mean ear weight of Tetradecanoyl phorbol acetate (TPA)-challenged murine treated with sertaconazole nitrate (1%) is 7.23 mg compared with 14.7 mg for controls, indicating a statistically significant reduction in irritant dermatitis. Sertaconazole nitrate 1% elicits a significant reduction in Resiniferatoxin-induced ear edema when compared with controls in CD-1 mice. Topical treatment with sertaconazole nitrate 1% significantly inhibits contact hypersensitivity and decreases the content of the pro-inflammatory cytokines TNFα, IL-2, and IFNγ in oxazolone exposed murine skin. [1] Clinical trials with sertaconazole nitrate cream 2% show efficacy in the treatment of superficial cutaneous fungal infections. [2] Sertaconazole reduces inflammation via inducing PGE2 production and the COX-2 inhibitor blocks sertaconazole from exerting its anti-inflammatory effects in a mouse model of TPA-induced ear edema. [3] The dermal administration of sertaconazole nitrate (2%) to rats, in which edema is induced by application of croton oil in the external ear, induced a 39.8% reduction of edema. [4] |
别名 | FI-7045, Ginedermofix, FI7056, Ertaczo, 硝酸舍他康唑 |
分子量 | 500.78 |
分子式 | C20H15Cl3N2OS·HNO3 |
CAS No. | 99592-39-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 93 mg/mL (185.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9969 mL | 9.9844 mL | 19.9688 mL | 49.9221 mL |
5 mM | 0.3994 mL | 1.9969 mL | 3.9938 mL | 9.9844 mL | |
10 mM | 0.1997 mL | 0.9984 mL | 1.9969 mL | 4.9922 mL | |
20 mM | 0.0998 mL | 0.4992 mL | 0.9984 mL | 2.4961 mL | |
50 mM | 0.0399 mL | 0.1997 mL | 0.3994 mL | 0.9984 mL | |
100 mM | 0.02 mL | 0.0998 mL | 0.1997 mL | 0.4992 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Sertaconazole nitrate 99592-39-9 Microbiology/Virology Antibiotic Antifungal COX-2 FI-7056 Inhibitor inhibit MCF-7 HaCaT Candida HeLa FI-7045 Ginedermofix FI7056 Ertaczo p38 MAPK A549 PGE2 Sertaconazole HEK-293 Apoptosis FI 7045 FI 7056 硝酸舍他康唑 Fungal Microtubule/Tubulin FI7045 Sertaconazole Nitrate Autophagy inhibitor