Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Seclidemstat (SP-2577) 是非竞争性可逆KDM1A (LSD1)抑制剂,可用于尤文肉瘤的研究。它促进 SWI/SNF 复合物突变卵巢癌的抗肿瘤免疫,并抑制病毒产生、病毒 DNA 复制和晚期基因表达。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 615 | 现货 | ||
2 mg | ¥ 891 | 现货 | ||
5 mg | ¥ 1,470 | 现货 | ||
10 mg | ¥ 2,390 | 现货 | ||
25 mg | ¥ 3,830 | 现货 | ||
50 mg | ¥ 5,490 | 现货 | ||
100 mg | ¥ 7,710 | 现货 | ||
200 mg | ¥ 10,300 | 现货 | ||
500 mg | ¥ 15,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 795 | 现货 |
产品描述 | Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM. |
靶点活性 | LSD1:127 nM |
体内活性 | Interstitial MR lymphography with gadopentetate dimeglumine (Gd-DTPA) allows clear visualization of the lymphatic pathway in healthy mice, and no significant difference is found between the two agents. Their rapid kinetics limits the imaging timing window, however, facilitates repeated assessment in a single imaging session [1]. Direct visualization of spilled gastrointestinal gadopentetate dimeglumine helps discriminate ischemic from control rats in this model [2]. |
别名 | SP-2577 |
分子量 | 450.94 |
分子式 | C20H23ClN4O4S |
CAS No. | 1423715-37-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 100 mg/mL (221.76 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2176 mL | 11.0879 mL | 22.1759 mL | 55.4397 mL |
5 mM | 0.4435 mL | 2.2176 mL | 4.4352 mL | 11.0879 mL | |
10 mM | 0.2218 mL | 1.1088 mL | 2.2176 mL | 5.544 mL | |
20 mM | 0.1109 mL | 0.5544 mL | 1.1088 mL | 2.772 mL | |
50 mM | 0.0444 mL | 0.2218 mL | 0.4435 mL | 1.1088 mL | |
100 mM | 0.0222 mL | 0.1109 mL | 0.2218 mL | 0.5544 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Seclidemstat 1423715-37-0 Chromatin/Epigenetic Histone Demethylase Inhibitor replication reversible SWI/SNF SP2577 SP 2577 complex antitumor SP-2577 Ewing DNA inhibit immunity Sarcoma inhibitor