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Scutebarbatine A

Scutebarbatine A

产品编号 TN2191   CAS 176520-13-1

Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.

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Scutebarbatine A Chemical Structure
Scutebarbatine A, CAS 176520-13-1
规格 价格/CNY 货期 数量
25 mg ¥ 10,600 待询
1 mL * 10 mM (in DMSO) ¥ 8,500 待询
产品目录号及名称: Scutebarbatine A (TN2191)
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存储 & 溶解度
参考文献
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产品描述 Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspase-3 and 9, and down-regulating Bcl-2. Scutebarbatine A and barbatine A show a significant ability to protect cells against H2O2 with ED50 values of 5.0 and 16.8 μM, respectively.
体外活性 The cytotoxic effect of Scutebarbatine A on A549 in vitro were determined by an MTT assay and evaluated by IC50 values. Furthermore, results of Hoechst 33258 and Annexin V/PI staining assays demonstrated that Scutebarbatine A had significant antitumor effects on A549 cells via apoptosis, in a concentration-dependent manner. What's more, the mechanism was explored by western blotting, and our study revealed that Scutebarbatine A can up-regulate the expressions of cytochrome c, caspase-3 and 9, and down-regulate the levels of Bcl-2 in A549 cells. Finally, the antitumor effects of Scutebarbatine A were evaluated in vivo by using transplanted tumor nude mice, and the results confirmed that Scutebarbatine A has a notable antitumor effect on A549 cancer via mitochondria-mediated apoptosis.
分子量 558.62
分子式 C32H34N2O7
CAS No. 176520-13-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. In vitro and in vivo antitumor activity of scutebarbatine A on human lung carcinoma A549 cell lines.Molecules. 2014 Jun 25;19(7):8740-51.
BI-3812 Rasagiline Diphenyl disulfide BDA-366 PROTAC Mcl1 degrader-1 Obovatol Myricanol Isoverticine

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母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Scutebarbatine A 176520-13-1 Apoptosis Proteases/Proteasome Caspase BCL Inhibitor inhibitor inhibit

 

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