Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.36 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 255 | 现货 | ||
10 mg | ¥ 418 | 现货 | ||
25 mg | ¥ 854 | 待询 | ||
50 mg | ¥ 1,280 | 待询 | ||
100 mg | ¥ 1,980 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 479 | 现货 |
产品描述 | Saquinavir (Ro 31-8959) is a potent HIV protease inhibitor, is an antiretroviral drug used together with other medications to treat or prevent HIV/AIDS. |
体内活性 | The AUC was not affected by grapefruit juice after intravenous administration, but it increased significantly from 76+/-96 (water, mean (s.d.) to 114+/-70 (microg l[-1] h) (grapefruit juice) after oral saquinavir. Similarly, the oral bioavailability of saquinavir increased by a factor of 2 with grapefruit juice (from 0.7% to 1.4%). In contrast, clearance, volume of distribution and elimination half-life of saquinavir were not affected by grapefruit juice. After oral, but not after intravenous administration, the plasma concentration-time curve showed a second peak after lunch irrespective of pretreatment, suggesting enhancement of absorption by food[1]. |
动物实验 | After an overnight fast, eight healthy volunteers were treated with either 400 ml grapefruit juice or water before intravenous (12 mg) or oral saquinavir (600 mg) was administered.?Serial blood samples were obtained over the following 24 h and standardized meals were served 5 and 10 h after the administration of saquinavir.?The plasma concentrations of saquinavir were determined by high-performance liquid chromatography and pharmacokinetic parameters were calculated by routine methods[1]. |
别名 | Ro 31-8959, 沙奎那韦 |
分子量 | 670.84 |
分子式 | C38H50N6O5 |
CAS No. | 127779-20-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (149.07 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.4907 mL | 7.4533 mL | 14.9067 mL | 37.2667 mL |
5 mM | 0.2981 mL | 1.4907 mL | 2.9813 mL | 7.4533 mL | |
10 mM | 0.1491 mL | 0.7453 mL | 1.4907 mL | 3.7267 mL | |
20 mM | 0.0745 mL | 0.3727 mL | 0.7453 mL | 1.8633 mL | |
50 mM | 0.0298 mL | 0.1491 mL | 0.2981 mL | 0.7453 mL | |
100 mM | 0.0149 mL | 0.0745 mL | 0.1491 mL | 0.3727 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Saquinavir 127779-20-8 Microbiology/Virology Proteases/Proteasome SARS-CoV HIV Protease HIV Ro 31-8959 Human immunodeficiency virus Inhibitor inhibit SARS coronavirus 沙奎那韦 inhibitor