Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STAT5-IN-1 (STAT5 Inhibitor) 是STAT5的抑制剂,对 STAT5β 亚型的IC50值为 47 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 196 | 现货 | ||
5 mg | ¥ 455 | 现货 | ||
10 mg | ¥ 728 | 现货 | ||
25 mg | ¥ 1,380 | 现货 | ||
50 mg | ¥ 2,280 | 现货 | ||
100 mg | ¥ 3,270 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 490 | 现货 |
产品描述 | STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
靶点活性 | STAT5:47 μM |
体外活性 | The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins that are implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members. |
别名 | STAT5 Inhibitor |
分子量 | 293.28 |
分子式 | C16H11N3O3 |
CAS No. | 285986-31-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (170.49 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.4097 mL | 17.0486 mL | 34.0971 mL | 85.2428 mL |
5 mM | 0.6819 mL | 3.4097 mL | 6.8194 mL | 17.0486 mL | |
10 mM | 0.341 mL | 1.7049 mL | 3.4097 mL | 8.5243 mL | |
20 mM | 0.1705 mL | 0.8524 mL | 1.7049 mL | 4.2621 mL | |
50 mM | 0.0682 mL | 0.341 mL | 0.6819 mL | 1.7049 mL | |
100 mM | 0.0341 mL | 0.1705 mL | 0.341 mL | 0.8524 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
STAT5-IN-1 285986-31-4 JAK/STAT signaling Stem Cells STAT STAT-5-IN-1 STAT5IN1 inhibit STAT5 IN 1 STAT5 Inhibitor Inhibitor inhibitor