Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ST034307 是一种选择性 adenylyl cyclase 1抑制剂,IC50值为 2.3 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 273 | 现货 | ||
2 mg | ¥ 389 | 现货 | ||
5 mg | ¥ 638 | 现货 | ||
10 mg | ¥ 970 | 现货 | ||
25 mg | ¥ 2,160 | 现货 | ||
50 mg | ¥ 3,820 | 现货 | ||
100 mg | ¥ 5,550 | 现货 | ||
500 mg | ¥ 11,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 688 | 现货 |
产品描述 | ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
靶点活性 | AC1:2.3 μM |
体外活性 | ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1]. |
体内活性 | ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1]. |
分子量 | 297.95 |
分子式 | C10H4Cl4O2 |
CAS No. | 133406-29-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (167.81 mM), sonification/heating is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3563 mL | 16.7813 mL | 33.5627 mL | 83.9067 mL |
5 mM | 0.6713 mL | 3.3563 mL | 6.7125 mL | 16.7813 mL | |
10 mM | 0.3356 mL | 1.6781 mL | 3.3563 mL | 8.3907 mL | |
20 mM | 0.1678 mL | 0.8391 mL | 1.6781 mL | 4.1953 mL | |
50 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6781 mL | |
100 mM | 0.0336 mL | 0.1678 mL | 0.3356 mL | 0.8391 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ST034307 133406-29-8 Neuroscience Adenylyl cyclase Adenylate Cyclase Inhibitor ST-034307 inhibit ST 034307 inhibitor