Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) 是高选择性非竞争性 mGlu5 受体拮抗剂 (IC50:0.4 μM) 。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 497 | 现货 | ||
2 mg | ¥ 745 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,870 | 现货 | ||
25 mg | ¥ 3,320 | 现货 | ||
50 mg | ¥ 4,820 | 现货 | ||
100 mg | ¥ 6,660 | 现货 | ||
500 mg | ¥ 13,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,130 | 现货 |
产品描述 | SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM) |
靶点活性 | hmGlu5:0.4 μM |
体内活性 | SIB-1757 was given by either intrathecal (i.th.), subcutaneous (s.c.) or intraplantar (i.pl.) injection.?In SNL rats, i.th.?SIB-1757 produced a partial reversal of tactile allodynia with a shallow dose-response curve ranging over three-orders of magnitude;?SIB-1757 was inactive against allodynia when given systemically.?SIB-1757 produced full reversal of thermal hyperalgesia in SNL rats following administration either spinally or locally to the injured paw;?administration to the contralateral paw had no effect.?SIB-1757 did not produce antinociception in either the SNL or sham-operated rats by any route[1]. |
别名 | 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 |
分子量 | 213.24 |
分子式 | C12H11N3O |
CAS No. | 31993-01-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 17 mg/ml(79.72 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.6896 mL | 23.4478 mL | 46.8955 mL | 117.2388 mL |
5 mM | 0.9379 mL | 4.6896 mL | 9.3791 mL | 23.4478 mL | |
10 mM | 0.469 mL | 2.3448 mL | 4.6896 mL | 11.7239 mL | |
20 mM | 0.2345 mL | 1.1724 mL | 2.3448 mL | 5.8619 mL | |
50 mM | 0.0938 mL | 0.469 mL | 0.9379 mL | 2.3448 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SIB-1757 31993-01-8 Neuroscience GluR mGluR 6-methyl-2-[(E)-phenyldiazenyl]pyridin-3 SIB 1757 Metabotropic glutamate receptors SIB1757 inhibit Inhibitor 6-methyl-2-[phenyldiazenyl]pyridin-3 inhibitor