Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SI-113 是一种有效的选择性 SGK1 抑制剂,SGK1 是一种丝氨酸/苏氨酸蛋白激酶,可调节多种致癌信号级联反应。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 297 | 现货 | ||
2 mg | ¥ 443 | 现货 | ||
5 mg | ¥ 728 | 现货 | ||
10 mg | ¥ 1,160 | 现货 | ||
25 mg | ¥ 2,120 | 现货 | ||
50 mg | ¥ 3,170 | 现货 | ||
100 mg | ¥ 4,550 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 862 | 现货 |
产品描述 | SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades. |
体外活性 | Cell viability, cell death, caspase activation and cell cycle progression were then analyzed by FACS and WB-based assays, after exposure to SI113, with or without oxidative stress and ionizing radiations. Moreover, autophagy and related reticulum stress response were evaluated. We show here, that i) SGK1 is over-expressed in highly malignant gliomas and that the treatment with SI113 leads to ii) significant increase in caspase-mediated apoptotic cell death in GBM cell lines but not in normal fibroblasts; iii)enhancement of the effects of ionizing radiations; iv) modulation of the response to oxidative reticulum stress; v) induction of cytotoxic autophagy[2]. |
分子量 | 400.48 |
分子式 | C23H24N6O |
CAS No. | 1392816-46-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (162.31 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.497 mL | 12.485 mL | 24.97 mL | 62.4251 mL |
5 mM | 0.4994 mL | 2.497 mL | 4.994 mL | 12.485 mL | |
10 mM | 0.2497 mL | 1.2485 mL | 2.497 mL | 6.2425 mL | |
20 mM | 0.1249 mL | 0.6243 mL | 1.2485 mL | 3.1213 mL | |
50 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL | |
100 mM | 0.025 mL | 0.1249 mL | 0.2497 mL | 0.6243 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SI-113 1392816-46-4 Metabolism SGK SI 113 SI113 Inhibitor inhibitor inhibit