Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB273005 是一种有效的整合素抑制剂,对 αvβ3 受体和 αvβ5 受体的 Ki 分别为 1.2 nM 和 0.3 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 4-6周 | ||
50 mg | ¥ 13,800 | 4-6周 | ||
1 mL * 10 mM (in DMSO) | ¥ 7,000 | 4-6周 |
产品描述 | SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
靶点活性 | αvβ5 receptor:0.3 nM, αvβ3 receptor:1.2 nM |
体外活性 | In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. [1] In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM). [3] |
体内活性 | In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. [1] In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. [2] SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. [4] In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels. [5] |
分子量 | 451.44 |
分子式 | C22H24F3N3O4 |
CAS No. | 205678-31-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: <1 mg/mL
Ethanol: 10 mg/mL(22.2 mM)
DMSO: 83 mg/mL (183.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.2151 mL | 11.0757 mL | 22.1513 mL | 55.3783 mL |
5 mM | 0.443 mL | 2.2151 mL | 4.4303 mL | 11.0757 mL | |
10 mM | 0.2215 mL | 1.1076 mL | 2.2151 mL | 5.5378 mL | |
20 mM | 0.1108 mL | 0.5538 mL | 1.1076 mL | 2.7689 mL | |
DMSO | 50 mM | 0.0443 mL | 0.2215 mL | 0.443 mL | 1.1076 mL |
100 mM | 0.0222 mL | 0.1108 mL | 0.2215 mL | 0.5538 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SB273005 205678-31-5 Cytoskeletal Signaling Integrin Inhibitor SB-273005 inhibit SB 273005 inhibitor