Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 770 | 4-5周 | ||
5 mg | ¥ 1,980 | 4-5周 | ||
10 mg | ¥ 3,370 | 4-5周 | ||
25 mg | ¥ 7,450 | 4-5周 |
SB-277011 dihydrochloride 的其他形式现货产品:
产品描述 | SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
靶点活性 | 5-HT1D receptor:5.9(pki), D2 receptor:6 (pki), 5-HT1B receptor:<5.2 (pki), D3 receptor:pki: 8.0 |
体外活性 | SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively). |
体内活性 | the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats. |
别名 | SB-277011A dihydrochloride |
分子量 | 511.49 |
分子式 | C28H32Cl2N4O |
CAS No. | 1226917-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SB-277011 dihydrochloride 1226917-67-4 GPCR/G Protein Neuroscience Dopamine Receptor SB-277011A SB-277011 SB277011 Dihydrochloride SB-277011A Dihydrochloride SB277011 dihydrochloride SB-277011 Dihydrochloride SB277011 SB 277011 Dihydrochloride SB-277011A dihydrochloride SB 277011 dihydrochloride SB 277011 Inhibitor inhibitor inhibit